With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.,103-76-4
Take piperazine ethanol 3.0g in 100ml round bottom flask, another 5.5g di-tert-butyl dicarbonate dissolved in 15ml of tetrahydroFuran, the solution was slowly added dropwise to the round-bottomed flask, stirred at room temperature for 4 hours until TLC detected nicotineethanol consumed. Most of the solvent is removed by rotary evaporation and the residue is diluted with water and extracted three times with dichloromethane (50 ml each). The organic phases were combined and dried over anhydrous sodium sulfate to give an oily liquid.This oily liquid was dissolved in 300 ml of methylene chloride and 3.34 ml of thionyl chloride was added slowly at room temperature and the mixture was stirred overnight at room temperature.The reaction mixture was diluted with water and adjusted to pH neutral with a solid of sodium bicarbonate. The organic phase was separated, dried over anhydrous sodium sulfate and dried to give 3.16 g of intermediate A22. Two-step yield of 55%.
The synthetic route of 103-76-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Tsinghua University; Rao Yu; Wu Wei; Lan Tianlong; Hu Jiantao; Fan Zhongyun; Huang Binlu; (31 pag.)CN107286098; (2017); A;,
Piperazine – Wikipedia
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