192130-34-0, tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
192130-34-0, To a suspension of 2-(4-(6-((2-(piperidin-1 -yl)ethyl)carbamoyl)-1 H-benzo[d]imidazol- 2-yl)phenyl)-1 H-benzo[d]imidazole-6-carboxylic acid (0.20 g, 0.39 mmol; crude) in DMF (5 ml.) at 0 C, was added HATU (0.18 g, 0.47 mmol), DIPEA (0.13 ml_, 0.78 mmol) and tert-butyl 4-(2- aminoethyl)piperazine-1 -carboxylate (71 mg, 0.31 mmol) to the above mixture at 0 C and the reaction mixture was allowed to warm to room temperature and stirred for 12 h. The reaction mixture was poured in to water and stirred for 15 mins, whereupon the product precipitated.The product was purified by prep HPLC on an X- bridge C181 Opm (30 c 150 mm, 10 pm) column; mobile phase, A= 0.1% TFA in H20 and B= CH3CN; Flow rate: 40 mL/min, Injection volume: 400 mI_, Runtime: 20 min, gradient: 90-65%A, 10-35% B (0.0-15 min); (UV detection at 220 nm). Fractions containing only the pure product were combined and concentrated under reduced pressure to obtain tert-butyl 4-(2-(2-(4-(6-((2-(piperidin-1 -yl)ethyl)carbamoyl)-1 H- benzo[d]imidazol-2-yl)phenyl)-1 H-benzo[d]imidazole-6-carboxamido)ethyl)piperazine-1 – carboxylate.
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Reference£º
Patent; THE SCRIPPS RESEARCH INSTITUTE; EXPANSION THERAPEUTICS, INC.; DISNEY, Matthew; BLIZZARD, Timothy, Allen; RZUCZEK, Suzanne; NDUNGU, John; VACCA, Joseph; JENNINGS, Andy; PUSHECHNIKOV, Alexei; (333 pag.)WO2019/99777; (2019); A2;,
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