With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of ethyl 2-bromo-3-oxo-3-(4-phenoxyphenyl)propanoate 4 (362 mg, 1 mmol) in ethanol (10 mL)was added tert-butyl 4-carbamothioylpiperazine-l-carboxylate 3 (245 mg, 1 mmol) at ambient temperature. The mixture was then heated to reflux and stirred for 2 h. After cooling to ambient temperature, the solvent was removed and the residue was purified by silica gel column chromatography eluting with 40: 1 to 20: 1 DCM/MeOH to afford the title compound (214 mg, 52%) as brown solid. MS (ESI): m/z = 410.1 [M + H]+.
196811-66-2, 196811-66-2 tert-Butyl 4-carbamothioylpiperazine-1-carboxylate 12093220, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; X-RX DISCOVERY, INC.; CHEN, Xiangyang; GAO, Yingxiang; LIU, Chong; NI, Haihong; MULVIHILL, Mark; WO2015/48662; (2015); A2;,
Piperazine – Wikipedia
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