With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.
TRV 1094[00289] To a degassed solution of 5-bromo-2-chloro-N-phenylaniline (172 mg, 0.61 mmol), phenyl(piperazin- l -yl)methanonein, ( 139mg, 0.73 mmol), Cs2C03 ( 396mg, 1.22 mmol), BINAP ( 18.9 mg, 0.03 mmol) in toluene was charged Pd2(dba)3 ( 27.9 mg, 0.03 mmol). The reaction was sealed under an atmosphere of argon and heated to 100 C for 7h. The mixture was cooled, filtered through celite, washed with ethyl acetate and then concentrated in vacuum. The residue was subjected to silica gel column chromatography (60 % hexane/ ethyl acetate) to furnish the title compound (4-(4-chloro-3-(phenylamino)phenyl)piperazin- l -yl)(phenyl)methanone, TRV 1094 as a colorless solid ( 168mg, 0.43 mmol) 70%. NMR (500 MHz, CDC13) delta (ppm) 3.02-3.95 (m, 8H), 6.09 (bs, 1H), 6.45 (m, 1 H), 6.86 (d, J = 2 Hz, 1 H), 7.08 (t, J = 7.5Hz, 1 H), 7.19 (m, 2H), 7.24 (d, J = 8.5 Hz, 1 H), 7.36 (m, 2H), 7.40-7.50 (m, 5H
13754-38-6, As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.
Reference£º
Patent; TREVENTIS CORPORATION; REED, Mark, A.; YADAV, Arun; BANFIELD, Scott, C.; BARDEN, Christopher, J.; WO2012/119035; (2012); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics