5317-33-9, 3-(4-Methylpiperazin-1-yl)propan-1-ol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
5317-33-9, Sodium metal (10.1 mmol, 0.23 g) was added to a solution of 3-N-(4-methylpiperazinyl)propan-1-ol (6.71 mmol, 1.06 g) in THF (15 mL) under N2. The resulting suspension was stirred at 20 C. for 2 hours and then cannulated into a solution of 7-fluoro-4-[(3-methylphenyl)amino]-6-nitroquinazoline (0.50 g, 1.68 mmol) in THF (20 mL) under N2. The dark red solution was then heated at reflux for 24 hours before being diluted with water and extracted with EtOAc. The combined organic extracts were dried over anhydrous Na2SO4, concentrated under reduced pressure and chromatographed on alumina eluting with EtOAc/hexane (1:1) to EtOAc (2:3:5), to give 4-[(3-methylphenyl)amino]-7-[3-N-(4-methylpiperazinyl)propyloxy]-6-nitroquinazoline (0.67 g, 91%) as a yellow powder, mp (Et2O/hexane) 155-156 C. 1H NMR [(CD3)2SO]: delta 10.00 (s, 1H, NH), 9.26 (s, 1H, H5, H2H5), 8.61 (s, 1H, H2), 7.64 (br d, J=8.4 Hz, 1H, H-6′), 7.62 (br s, 1H, H-2′), 7.43 (s, 1H, H8), 7.29 (t, J=7.8 Hz, 1H, H-5′), 6.99 (br d, J=7.4 Hz, 1H, H-4′), 4.32 (t, J=6.0 Hz, 2H, CH2CH2CH2O), 2.44 (t, J=7.0 Hz, 2H, NCH2CH2CH2), 2.39-2.28 (br s, 8H, piperazinyl methylene), 2.34 (s, 3H, CH3Ar), 2.14 (s, 3H, CH3N), 1.92 (quintet, J=6.6 Hz, 2H, CH2CH2CH2). Analysis calculated for CH28N6O3 requires: C, 63.3; H, 6.5; N, 19.3%. Found: C, 63.4; H, 6.8; N, 19.6%.
As the paragraph descriping shows that 5317-33-9 is playing an increasingly important role.
Reference£º
Patent; Warner-Lambert Company; US6344459; (2002); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics