With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25057-77-6,1,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of N-(l-(lH-indol-3-yl)hexan-2-yl)-2-bromothiazole-5- carboxamide (0.20 g, 0.49 mmol) and 1,2-dimethylpiperazine (0.06 g, 0.54 mmol) in CH3CN (4.5 mL) was added K2C03 (0.20 g, 1.47 mmol) and the reaction mixture was heated at 80 C for 16 h. The reaction mixture was concentrated in vacuo. The residue was diluted with H20 (10 mL) and extracted with 10% MeOH in DCM (10 mL). The organic layer was separated, dried over anhydrous Na2S04 and concentrated in vacuo. The crude obtained was purified by column chromatography (silica 230-400 mesh, 0.5 to 3.5% MeOH in DCM) and triturating with pentane (10 mL) to afford N-(l-(lH-indol-3-yl) hexan-2-yl)-2-(3,4-dimethylpiperazin-l- yl)thiazole-5-carboxamide (0.075 g, 34%) as a white solid. HPLC Purity: 99.2%. LC/MS (ESI) m/e [M+H]+/RT (min)/%: 440.00/2.76/99.8%. 1H NMR (400 MHz, DMSO-d6) delta 0.81 (t, = 6.9 Hz, 3H), 1.02 (d, = 6.4 Hz, 3H), 1.18-1.31 (m, 4H), 1.40-1.60 (m, 2H), 2.06-2.18 (m, 2H), 2.20 (s, 3H), 2.69-2.91 (m, 4H), 3.10-3.22 (m, 1H), 3.64-3.77 (m, 2H), 4.11 (d, = 4.4 Hz, 1H), 6.91-6.99 (m, 1H), 7.04 (t, = 7.6 Hz, 1H), 7.09 (brs, 1H), 7.31 (d, = 7.8 Hz, 1H), 7.57 (d, = 7.8 Hz, 1H), 7.80 (s, 1H), 7.93 (d, = 8.3 Hz, 1H), 10.75 (brs, 1H)., 25057-77-6
The synthetic route of 25057-77-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; NEUROPORE THERAPIES, INC.; WRASIDLO, Wolfgang; STOCKING, Emily, M.; HALL, Adrian; MACCOSS, Malcolm; (139 pag.)WO2017/20010; (2017); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics