Simple exploration of 55112-42-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55112-42-0,4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride,as a common compound, the synthetic route is as follows.

55112-42-0, Example 7: Preparation of Zopiclone in acetonitrile[0070] To a slurry of 1 -chlorocarbonyl-4-methyl piperazine hydrochloride(CMP) (5.67g) in acetonitrile (ACN) (150 ml), mechanically stirred under nitrogen at O0C, were added Na2CO3 (4.98 g) and DMAP (0.46g) followed by addition of 7-OH- Py (5g). The reaction mixture was then stirred at 2C for 1.5h, under nitrogen followed by 18h stirring at room temperature and a few hours at reflux. After the reaction completion, the solvent was evaporated, to give a solid that was re-dissolved in Ethyl acetate and water. Phases were separated and the aqueous phase was extracted with Ethyl acetate. The solid formed in the aqueous layer was filtered to give zopiclone crude product (6.13g, yield 64.9%; purity 99.85% by HPLC).

55112-42-0 4-Methyl-1-piperazinecarbonyl Chloride Hydrochloride 3016934, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/2629; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics