Synthesis, biological evaluation and structure-activity correlation study of a series of imidazol-based compounds as Candida albicans inhibitors was written by Moraca, Francesca;De Vita, Daniela;Pandolfi, Fabiana;Di Santo, Roberto;Costi, Roberta;Cirilli, Roberto;D’Auria, Felicia Diodata;Panella, Simona;Palamara, Anna Teresa;Simonetti, Giovanna;Botta, Maurizio;Scipione, Luigi. And the article was included in European Journal of Medicinal Chemistry in 2014.Recommanded Product: 87394-48-7 This article mentions the following:
A new series of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives was synthesized. The antifungal activity was evaluated in vitro against different fungal species. The biol. results show that the most active compounds possess an antifungal activity comparable or higher than Fluconazole against Candida albicans, non-albicans Candida species, Cryptococcus neoformans and dermathophytes. Because of their racemic nature, the most active compounds I and II were tested as pure enantiomers. For II the (R)-enantiomer resulted more active than the (S)-one, otherwise for 5f the (S)-enantiomer resulted the most active. To rationalize the exptl. data, a ligand-based computational study was carried out; the results of the modeling study show that (S)-I and (R)-II perfectly align to the ligand-based model, showing the same relative configuration. Preliminary studies on the human lung adenocarcinoma epithelial cells (A549) have shown that II, III and I possess a low cytotoxicity. In the experiment, the researchers used many compounds, for example, 1-(3-Nitropyridin-2-yl)piperazine (cas: 87394-48-7Recommanded Product: 87394-48-7).
1-(3-Nitropyridin-2-yl)piperazine (cas: 87394-48-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Recommanded Product: 87394-48-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics