Diamidines versus monoamidines as anti-Pneumocystis agents: an in vivo study was written by Stanicki, Dimitri;Pottier, Muriel;Gantois, Nausicaa;Pincon, Claire;Forge, Delphine;Mahieu, Isabelle;Boutry, Sebastien;Vanden Eynde, Jean Jacques;Martinez, Ann;Dei-Cas, Eduardo;Aliouat, El-Moukhtar. And the article was included in Pharmaceuticals in 2013.Category: piperazines This article mentions the following:
Some compounds articulated around a piperazine or an ethylenediamine linker have been evaluated in vitro to determine their activity in the presence of a 3T6 fibroblast cell line and an axenic culture of Pneumocystis carinii, resp. The most efficient antifungal derivatives, namely N,N’-bis(benzamidine-4-yl)ethane-1,2-diamine (compound 6, a diamidine) and N-(benzamidine-4-yl)-N’-phenylethane-1,2-diamine (compound 7, a monoamidine), exhibited no cytotoxicity and were evaluated in vivo in a rat model. Only the diamidine 6 emerged as a promising hit for further studies. In the experiment, the researchers used many compounds, for example, 4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1Category: piperazines).
4,4′-(Piperazine-1,4-diyl)dianiline (cas: 7479-12-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics