Month: February 2023

McManus, Joshua B. et al. published their research in Organic Letters in 2020 | CAS: 780705-64-8

tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Formula: C13H20N4O2

Site-Selective C-H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis was written by McManus, Joshua B.;Onuska, Nicholas P. R.;Jeffreys, Matthew S.;Goodwin, Nicole C.;Nicewicz, David A.. And the article was included in Organic Letters in 2020.Formula: C13H20N4O2 This article mentions the following:

Substituted piperazines such as I were prepared by C-H alkylation of piperazines such as tert-Bu 4-benzoyl-1-piperazinecarboxylate with electron-deficient alkenes such as PhCH:C(CN)2 under blue LED irradiation in the presence of a diarylacridinium salt as a photoredox catalyst. The regioselectivity of the photoredox alkylation reactions was correlated to the difference between the calculated electron populations at the nitrogen atoms of the neutral compounds and the calculated electron populations at the nitrogen atoms of the radical cations. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8Formula: C13H20N4O2).

tert-Butyl 4-(pyrimidin-2-yl)piperazine-1-carboxylate (cas: 780705-64-8) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Formula: C13H20N4O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Kikumoto, Ryoji et al. published their research in Journal of Medicinal Chemistry in 1984 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C7H16N2

Substituted (ω-aminoalkoxy)stilbene derivatives as a new class of anticonvulsants was written by Kikumoto, Ryoji;Tobe, Akihiro;Fukami, Harukazu;Ninomiya, Kunihiro;Egawa, Mitsuo. And the article was included in Journal of Medicinal Chemistry in 1984.Synthetic Route of C7H16N2 This article mentions the following:

(ω-Aminoalkoxy)stilbenes I [R1 = H, Cl, F, 2-MeO, 2-Me, 3,4-Cl2; R2 = H, 3-MeO, 5-Cl; R3 = NMe2, NEt2, NHMe, NPr2, 1-pyrrolidinyl, 1-piperidinyl, morpholino, 4-alkyl-1-piperazinyl, 3-R4-substituted-1-piperidinyl (R4 = OH, alkoxy, OAc, CH2OH, CONH2, CO2Me, Me, CO2H); n = 2-5] and II (butoxy at 2, 3, 4) were prepared by successive Grignard reaction of benzyl chlorides III with salicylaldehydes IV, dehydration of (1-hydroxyphenethyl)phenols, ω-bromoalkylation of hydroxy-trans-stilbenes, and amination of the product bromoalkyl ethers with amines. The effect of structural modification of these mols. on the activities was examined Potent anticonvulsant activity was displayed by 2-[4-(4-methyl-1-piperazinyl)butoxy]stilbene and piperidinobutoxystilbene derivatives V (R4 = OH, OMe, OEt, and OAc) as determined by maximal electroshock seizure (MES) and pentylenetetrazol-induced convulsion tests in mice. V (R4 = OH) exhibited more potent anti-MES activity than diphenylhydantoin and carbamazepine in further pharmacol. tests in rats, and its therapeutic index was superior to those of two antiepileptic drugs. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Synthetic Route of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Lory, Pedro M. J. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2007 | CAS: 149554-29-0

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 6-(Piperazin-1-yl)nicotinonitrile

Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides was written by Lory, Pedro M. J.;Estrella-Jimenez, Maria E.;Shashack, Matthew J.;Lokesh, Ganesh L.;Natarajan, Amarnath;Gilbertson, Scott R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Quality Control of 6-(Piperazin-1-yl)nicotinonitrile This article mentions the following:

Methods appropriate for the parallel synthesis of libraries based on the thioxanthen-9-one 10,10-dioxide scaffold are reported. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and com. available 3-carboxythioxanthen-9-one 10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alk. phosphatase reported replicon system for activity against hepatitis C virus. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0Quality Control of 6-(Piperazin-1-yl)nicotinonitrile).

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 6-(Piperazin-1-yl)nicotinonitrile

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Gao, Shouhai et al. published their research in Zhongguo Yaowu Huaxue Zazhi in 1993 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Application of 21867-64-1

Syntheses of Mannich basic compounds of tetrahydronaphthol containing piperazine side chains was written by Gao, Shouhai;Li, Fulin. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 1993.Application of 21867-64-1 This article mentions the following:

Title compounds I (R = Me, Et, Pr, Me2CH, Bu, iso-Bu, EtCHMe, pentyl, isopentyl) were prepared starting from 1-naphthol. I (R = Bu, EtCHMe, isopentyl) showed antimalarial activity comparable to that of chloroquine. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Application of 21867-64-1).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Application of 21867-64-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Yoshida, Tomohiro et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2007 | CAS: 149554-29-0

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C10H12N4

[(S)-γ-(4-Aryl-1-piperazinyl)-L-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors was written by Yoshida, Tomohiro;Sakashita, Hiroshi;Akahoshi, Fumihiko;Hayashi, Yoshiharu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.COA of Formula: C10H12N4 This article mentions the following:

In the search for an inhibitor of dipeptidyl peptidase IV (DPP-IV) highly potent both in vitro and in vivo, a series of L-prolylthiazolidine-based DPP-IV inhibitors, e.g., I, having 4-arylpiperazine or 4-arylpiperidine at the γ-position of the proline structure was synthesized. Of these compounds, the 4-(5-nitro-2-pyridyl)piperazine analog I showed a sub-nanomolar (IC50 = 0.92 nmol/L) DPP-IV inhibitory activity and a long-lasting in vivo DPP-IV inhibition profile. In the experiment, the researchers used many compounds, for example, 6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0COA of Formula: C10H12N4).

6-(Piperazin-1-yl)nicotinonitrile (cas: 149554-29-0) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C10H12N4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wiles, Charlotte et al. published their research in Lab on a Chip in 2007 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H16N2

The use of solid-supported reagents for the multi-step synthesis of analytically pure α,β-unsaturated compounds in miniaturized flow reactors was written by Wiles, Charlotte;Watts, Paul;Haswell, Stephen J.. And the article was included in Lab on a Chip in 2007.Electric Literature of C7H16N2 This article mentions the following:

Micro reaction technol. offers a safe, controllable and information rich technique suitable for the long-term production of pharmaceutical agents and fine chems. To date however, few of the syntheses performed using this technol. have addressed the problems associated with product purification The incorporation of multiple supported reagents into EOF-based miniaturized flow reactors for the two-step synthesis of anal. pure compounds is reported. Using this approach, the successful synthesis of 20 α,β-unsaturated compounds in excellent yields (>99.1%) and purities (>99.9%) has been achieved, illustrating significant improvements compared to traditional batch techniques. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Electric Literature of C7H16N2).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Electric Literature of C7H16N2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Trifilenkov, A. S. et al. published their research in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Category: piperazines

Liquid-phase parallel synthesis of 4-sulfanylbenzoic acid derivatives was written by Trifilenkov, A. S.;Il’in, A. P.;Kravchenko, D. V.;Dorogov, M. V.;Tkachenko, S. E.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2005.Category: piperazines This article mentions the following:

Combinatorial libraries of substituted 4-sulfanylbenzamides and their derivatives were synthesized on the basis of 4-fluoro-3-nitrobenzoic acid. The procedure for nucleophilic substitution of fluorine by various thiols has been developed; the resulting 4-sulfenyl-3-nitrobenzoic acids were further converted into the corresponding esters and amides. Oxidation of the sulfide fragment with hydrogen peroxide afforded the corresponding sulfones. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Category: piperazines).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Wang, Yu-Xia et al. published their research in Youji Huaxue in 2006 | CAS: 373608-48-1

tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Computed Properties of C12H25N3O2

Synthesis, interaction with DNA and bioactivity of N-piperazinoalkylamide was written by Wang, Yu-Xia;Zhao, Jin;Sun, Xin-Qi;Wang, Chao-Jie. And the article was included in Youji Huaxue in 2006.Computed Properties of C12H25N3O2 This article mentions the following:

Nine novel N-piperazinoalkylamide derivatives were synthesized and their structures were confirmed by 1H NMR, MS spectra and elemental anal. All the target compounds, together with the four com. drugs, naproxen, 4-biphenylacetic acid, brufen (as the acyl agents) and 5-fluorouracil, were tested in vitro for their inhibition on four kinds of human cancer cells, KB, A-549, MDA and Bel-7402. The data showed that all the synthesized compounds exhibited pos. effect on KB and Bel-7402 cells, but neg. effect on A-549 and MDA cells, while the com. medicines had the similar results unexpectedly. In addition, the inhibition rate of 4-biphenylacetic acid and naproxen on Bel-7402 cell was equivalent with 5-fluorouracil, while their inhibition on KB cell was higher than that of 5-fluorouracil. The inhibitory ability of the samples on tyrosine kinase was also measured, however no obvious effect was found. The fluorescence spectra of 13a and 4-biphenylacetic acid demonstrated that 13a did not show the interaction with DNA while 4-biphenylacetic acid exhibited the intercalary effect on DNA. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1Computed Properties of C12H25N3O2).

tert-Butyl 4-(3-aminopropyl)piperazine-1-carboxylate (cas: 373608-48-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Computed Properties of C12H25N3O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Gan, L. H. et al. published their research in Macromolecules in 2000 | CAS: 21867-64-1

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Recommanded Product: 1-Propylpiperazine

Poly(N-acryloyl-N’-propylpiperazine): A New Stimuli-Responsive Polymer was written by Gan, L. H.;Gan, Y. Y.;Deen, G. Roshan. And the article was included in Macromolecules in 2000.Recommanded Product: 1-Propylpiperazine This article mentions the following:

A new water-soluble stimuli-responsive poly(N-acryloyl-N’-propylpiperazine) (PAcrNPP) was synthesized and characterized. The polymer exhibited a lower critical solution temperature (LCST) in water at 37°. The phase transition temperature was highly sensitive to pH changes. The effects of some simple salts and cationic surfactants were studied. The enthalpy of phase separation determined by microcalorimetry was 21.4 kJ mol-1. This value corresponds to the breaking of one hydrogen bond per monomer unit. Dynamic light scattering studies indicated some aggregations of polymer chains below the LCST. No such aggregations were observed for the lower analogs, poly(N-acryloyl-N’-methylpiperazine) (PAcrNMP) and poly(N-acryloyl-N’-ethylpiperazine) (PAcrNEP) which exhibited no LCST. The crosslinked polymer gels were sensitive to both pH and temperature Their response time to swelling and deswelling was 150 min. The water sorption of the gels was non-Fickian under both acidic and neutral conditions. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Recommanded Product: 1-Propylpiperazine).

1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Recommanded Product: 1-Propylpiperazine

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Jin, Bo et al. published their research in Frontiers in Chemistry (Lausanne, Switzerland) in 2022 | CAS: 119285-07-3

tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 119285-07-3

Synthesis and biological evaluation of 3-(pyridine-3-yl)-2-oxazolidinone derivatives as antibacterial agents was written by Jin, Bo;Wang, Tong;Chen, Jia-yi;Liu, Xiao-qing;Zhang, Yi-xin;Zhang, Xiu-ying;Sheng, Zun-lai;Yang, Hong-Liang. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2022.Reference of 119285-07-3 This article mentions the following:

In this research, a series of 3-(pyridine-3-yl)-2-oxazolidinone derivatives I [R = (pyridin-3-yl)carbonyl, Me, N-cyclohexylcarbamoyl, etc.], II (X = F, H) was designed, synthesized, and evaluated for in vitro antibacterial activity, which included bacteriostatic, morphol., kinetic studies, and mol. docking. The results demonstrated that compounds II [R = cyclohexanecarbonyl, (2E)-3-(furan-2-yl)prop-2-enoyl (III), (2E)-3-(pyridin-3-yl)prop-2-enoyl, N-(4-chlorophenyl)carbamoyl; X = F] exhibited strong antibacterial activity similar to that of linezolid toward five Gram-pos. bacteria. After observing the effect of the drug on the morphol. and growth dynamics of the bacteria, the possible modes of action were predicted by mol. docking. Furthermore, the antibiofilm activity and the potential drug resistance assay were proceeded. These compounds exhibited universal antibiofilm activity and compound III showed significant concentration-dependent inhibition of biofilm formation. Compound III also showed a stable effect on S. pneumoniae (ATCC 49619) with less drug resistance growth for 15 days, which is much longer than that of linezolid. Overall, these results can be used to guide further exploration of novel antimicrobial agents. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3Reference of 119285-07-3).

tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 119285-07-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics