Month: February 2023

Power generation and autonomous glucose detection with an integrated array of abiotic fuel cells on a printed circuit board was written by Gonzalez-Solino, Carla;Bernalte, Elena;Metcalfe, Benjamin;Moschou, Despina;Di Lorenzo, Mirella. And the article was included in Journal of Power Sources in 2020.Safety of Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate This article mentions the following:

Wearable technologies can enable effective management of life-threatening diseases. In such systems, miniaturization leads to minimally invasive and light weight devices that, while ensuring safety, allow patients to perform their everyday activities freely. By generating direct and continuous energy from physiol. fluids at body temperature, glucose fuel cells (GFCs) provide an attractive and easy-to-miniaturize power source alternative to lithium batteries. In this context, we explore for the first time the use of printed circuit boards (PCBs) for the development of integrated arrays of abiotic GFCs and successfully demonstrate their operation at physiol. concentrations of glucose, both in a phosphate buffer and in synthetic interstitial fluid. Each GFC consists of a porous gold anode and a Pt/Au cathode in a single layer, and generates a maximum power of 14.3渭W cm^-2 (in 6 mM of glucose), with a linear response to glucose within a concentration range that includes hypo- and hyper-glycemic values. We also demonstrate linear power output scale-up by elec. connecting in parallel four GFCs on PCB. Considering the simplicity of the system architecture and the ease of integration provided by PCBs, our pioneering work paves the way for exciting opportunities in the field of self-powered wearable diagnostics. In the experiment, the researchers used many compounds, for example, Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate (cas: 75277-39-3Safety of Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate).

Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate (cas: 75277-39-3) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Safety of Sodium 2-(4-(2-hydroxyethyl)piperazin-1-yl)ethanesulfonate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Positive- and negative-ion mass spectrometry and rapid clean-up of 19 phenothiazines was written by Ishikawa, Yasunobu;Suzuki, Osamu;Hattori, Hideki. And the article was included in Forensic Science International in 1990.Product Details of 316-81-4 This article mentions the following:

Pos.-ion electron impact (PIEI), pos.-ion chem. ionization (PICI), and neg.-ion chem. ionization (NICI) mass spectra of 19 phenothiazines are presented. In the PIEI mode, peaks due to M, M minus side chain (M – R₁), M – R₁ + H, and side chain itself (R₁) appeared for most compounds The M – R₁ ions were very useful for drug screening. In the PICI mode, most spectra showed base or intense peaks due to M + H, and small peaks due to M + C₂H₅; peaks due to M – R₁ also appeared in many compounds In the NICI mode, fragmentation modes were different in different compound groups; mol. or [M – H]^– quasimol. anions appeared in many compounds with aliphatic side chains. Anions at m/z 98 and 115 were characteristic for compounds with (N-methylpiperazinyl)propyl side chains. Selected ion monitoring in the PIEI mode generally gave much higher sensitivity than in the PICI and NICI modes. Phenothiazines present in urine or plasma could be rapidly isolated by use of Sep-Pak C₁₈ cartridges. Thirteen of 19 phenothaizines could be detected by HP-17 wide-bore capillary gas chromatog. with satisfactory separation from impurities in their underivatized forms. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Product Details of 316-81-4).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Product Details of 316-81-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Impact of Heat Inactivation of Blood Samples on Therapeutic Drug Monitoring of 5 Second-Generation Antipsychotics and Their Metabolites was written by Ding, Jing;Yang, Liu;Zhang, Yan;Zhang, Suo;Meng, Zhuocheng. And the article was included in Therapeutic Drug Monitoring in 2022.COA of Formula: C23H25Cl2N3O2 This article mentions the following:

The severe acute respiratory syndrome coronavirus 2 outbreak has been classified as a pandemic. Because many coronaviruses are heat sensitive, heat inactivation of patient samples at 56掳C before testing reduces the risk of transmission. The aim of this study is to assess the impact of heat inactivation of patient blood samples on plasma concentrations of 5 second-generation antipsychotics and their metabolites. Blood samples were collected during routine clin. therapeutic drug monitoring examination between Apr. 3, 2021, and Apr. 19, 2021. Samples were divided into 2 groups: group A, noninactivated raw sample, and group B, inactivated samples. Inactivation was performed by a 30-min incubation at 56掳C. The levels of the 5 drugs and their metabolites before and after sample heat inactivation were measured using liquid chromatog.-tandem mass spectrometry and compared. Furthermore, correlation and Bland-Altman analyses were conducted. No statistically significant difference was observed between the levels of the 5 drugs and their metabolites (ie, risperidone, 9-OH-risperidone, aripiprazole, dehydroaripiprazole, olanzapine, quetiapine, norquetiapine, clozapine, and norclozapine) in the noninactivated group A and the inactivated group B (P 掳 0.05). Each drug鈥瞫 concentration values in inactivated and noninactivated treatments correlated (Spearman rs 掳 0.98; P 0.001). The results of the noninactivated treatment methods and samples alone showed good consistency via Bland-Altman anal. Blood sample heat inactivation had no significant effect on the therapeutic drug monitoring of 5 second-generation antipsychotics and their metabolites. This inactivated treatment method should be recommended to effectively protect laboratory staff from virus contamination. In the experiment, the researchers used many compounds, for example, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4COA of Formula: C23H25Cl2N3O2).

7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.COA of Formula: C23H25Cl2N3O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

An LD₅₀ model for predicting psychotropic drug toxicity using biopartitioning micellar chromatography was written by Quinones-Torrelo, C.;Sagrado-Vives, S.;Villanueva-Camanas, R. M.;Medina-Hernandez, M. J.. And the article was included in Biomedical Chromatography in 2001.Computed Properties of C22H30N4O2S2 This article mentions the following:

The LD₅₀ determination is the main way to measure the acute toxicity of all types of substances. At the present time, however, there is increasing opposition to the use of living animals in research and testing activities from animal rights groups as well as some scientists. Nevertheless, the need to have a tool for estimating the potential toxicity of new compounds for human consumption has encouraged the development of alternative methods. Under adequate conditions, the partitioning in micellar liquid chromatog. can describe the drug biopartitioning. We have named this chromatog. system biopartitioning micellar chromatog. (BMC). In this paper, an LD₅₀ QRAR model developed for psychotropic drugs from their retention data in BMC, is described. The model’s ability to predict new psychotropic drug toxicity is statistically proved. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Computed Properties of C22H30N4O2S2).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Computed Properties of C22H30N4O2S2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Discovery of benzo[d]oxazole derivatives as the potent type-I FLT3-ITD inhibitors was written by Bao, Jiyin;Liu, Haichun;Zhi, Yanle;Yang, Wenqianzi;Zhang, Jiawei;Lu, Tao;Wang, Yue;Lu, Shuai. And the article was included in Bioorganic Chemistry in 2020.Recommanded Product: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate This article mentions the following:

A series of compounds I [R¹ = H, Me, F, MeO; R² = diethylamino, piperidinyl, piperazin-1-yl, etc.; R³ = Ph, pyridin-3-yl, pyridin-4-yl, etc.] were designed and synthesized based on benzo[d]oxazole-2-amine scaffold to discover new potent Fms-like tyrosine kinase 3 inhibitors. During the medicinal chem. works, flexible mol. docking was used to provide design rationale and study the binding modes of the target compounds Through the mixed SAR exploration based on the enzymic and cellular activities, compound I [R¹ = MeO; R² = piperazin-1-yl; R³ = 3-carbamoylphenyl] was identified with potent FLT3-ITD inhibitory (IC₅₀: 0.41 nM) and anti-proliferative (IC₅₀: 0.037渭M against MV4-11 cells) activities. And the binding mode of I [R¹ = MeO; R² = piperazin-1-yl; R³ = 3-carbamoylphenyl] with ”DFG-in” FLT3 was simulated by a 20-ns mol. dynamics run, providing some insights into further medicinal chem. efforts toward novel FLT3 inhibitors in AML therapy. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8Recommanded Product: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate).

tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate (cas: 154590-34-8) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Recommanded Product: tert-Butyl 4-(2-fluoro-4-nitrophenyl)piperazine-1-carboxylate

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Novel 1D/3D CeO₂/g-C₃N₄ catalysts for photodegradation of ciprofloxacin under visible light via dimensional regulation and heterostructure construction was written by Zhou, Jie;Zhu, Beibei. And the article was included in Journal of Physics and Chemistry of Solids in 2022.Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid This article mentions the following:

Dimensional regulation and heterostructure building strategy are the significant means to boost the property of semiconductor photocatalysts. Herein, CeO₂/g-C₃N₄ (CeCN) composites with 1D/3D structure were synthesized by compounding one-dimensional CeO₂ nanorods and three-dimensional porous carbon nitride materials. Diverse characterization methods, BET, XRD, SEM/TEM, FT-IR, XPS and UV-vis DRS, to name a few, were conducted to reveal the surface area, micro shape, crystal structure, surface functional groups and photoconductive properties of the samples. The photocatalytic properties of catalyst were estimated by photodegradation of ciprofloxacin (CIP) under visible light irradiation The results suggested that CeO₂ nanorods with 1D structure and g-C₃N₄ with 3D porous structure are successfully composite into 1D/3D composites without any crystal structure and surface functional groups changed. The optimal CeCN25 exhibited brilliant photodegradation performance with 96.3% degradation efficiency within 100 min under visible light irradiation The dimension control strategy made the material form porous structure and increases the adsorption performance of the material, while the heterostructure construction strategy formed a space elec. field with efficient charge separation and transfer, which prolonged charge life. The combination of two strategies was the crucial factor for the eminent catalytic activity of photocatalysts. This work supplies thinking for the directional design and synthesis of composite catalysts with high photocatalytic activity. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder. was written by Takahashi, Tetsuya;Mitsuya, Hironori;Murata, Tetsuhito;Murayama, Junichi;Wada, Yuji. And the article was included in Sleep medicine in 2008.Computed Properties of C27H37N5O9 This article mentions the following:

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia defined by intermittent loss of electromyographic atonia during REM sleep with emergence of complex and vigorous behaviors. Although the efficacy of several agents for treating RBD has been reported, a rationale for medication has not been established and the exact pathophysiological mechanisms of RBD are uncertain. We encountered a patient with idiopathic RBD that dramatically improved with selective serotonin reuptake inhibitors (SSRIs) and deteriorated with a 5-HT1A partial agonist, tandospirone. We report on the effects of these serotonin-modulating agents, which yield clues to a possible pharmacological approach to RBD. In the experiment, the researchers used many compounds, for example, rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1Computed Properties of C27H37N5O9).

rel-(3aR,4S,7R,7aS)-2-(4-(4-(Pyrimidin-2-yl)piperazin-1-yl)butyl)hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione 2-hydroxypropane-1,2,3-tricarboxylate (cas: 112457-95-1) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Computed Properties of C27H37N5O9

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Microbiological analysis, antimicrobial activity, heavy-metals content and physico-chemical properties of Fijian mud pool samples was written by Pipite, Atanas;Siro, Galana;Subramani, Ramesh;Srinivasan, Sathiyaraj. And the article was included in Science of the Total Environment in 2023.Reference of 85721-33-1 This article mentions the following:

The hot springs are home to a rich bacterial diversity which could be the source of enzymes, antibiotics and many other com. important products. Most of the hot springs present in Fiji are unexplored and their anal. of microbial diversity could be of great interest in facilitating various industrial, agricultural and medicinal applications. This study is an attempt to evaluate the heavy metal concentration and to analyze the comprehensive bacterial diversity of two Fijian thermal mud pools, namely Sabeto and Tifajek. The two hot springs have a pH of 7.28 to 7.19 and a temperature of 32.2 to 38.8掳C, resp. Mean metal concentrations of the studied mud samples ranged from 4.758 to 6.870 mg/kg and followed a decreasing sequence as Fe > Mn > Zn > Na > Ni > Cd > Ca > Cr > Cu. Levels of Fe, Na, Mn, Zn, Ni, Cd, Ca, Cr, Cu in the mud pool samples were within World Health Organization (WHO) limits, while Cd was above regulatory limits. The heavy metals anal. results showed that both mud pools had high values for Cd, above the WHO limit of 3 mg/kg. In addition, 8 strains of actinomycetes were successfully identified for the first time in the Sabeto mud pool, where most of them showed antibacterial activity. The genetic identification of most isolates was determined in BLASTn analyses of their 16S rRNA sequences. Isolates were identified as that of Streptomyces, Nocardia and Rhodococcus genus. Further, AntiSMASH results of the closest relatives of cultured actinobacteria have shown to produce antibiotics, natural pesticides and other compounds of various usage. This study also found no fecal coliforms and supports existing knowledge and practice of using Fijian thermal mud pools for their therapeutic properties. Overall, the presented work indicated that the studied mud pools have therapeutic properties, harboring wealth of bacteria with antibiotic profiles and were risk free from health-related issues of heavy metals and disease-causing pathogens. It provides great insight into the studied mud pools which serves as a baseline from which further heavy metal monitoring or mitigation programs and microbial researches can be conducted. In the experiment, the researchers used many compounds, for example, 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1Reference of 85721-33-1).

1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 85721-33-1) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 85721-33-1

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Aripiprazole-Montmorillonite: A New Organic-Inorganic Nanohybrid Material for Biomedical Applications was written by Oh, Yeon-Ji;Choi, Goeun;Choy, Young Bin;Park, Je Won;Park, Jung Hyun;Lee, Hwa Jeong;Yoon, Yeo Joon;Chang, Hee Chul;Choy, Jin-Ho. And the article was included in Chemistry – A European Journal in 2013.Formula: C23H25Cl2N3O2 This article mentions the following:

Poor aqueous solubility and the unpleasant taste of aripiprazole (APZ) have been recurring problems, owing to its low bioavailability and low patient tolerance, resp. Herein, we prepared a nanohybrid system that was based on a bentonite clay material, montmorillonite (MMT), which could both mask the taste and enhance the solubility of APZ (i.e., APZ-MMT). To further improve the efficacy of this taste masking and drug solubility, APZ-MMT was also coated with a cationic polymer, polyvinylacetal diethylamino acetate (AEA). In vitro dissolution tests at neutral pH showed that the amount of drug that was released from the AEA-coated APZ-MMT was greatly suppressed (<1 %) for the first 3 min, thus suggesting that AEA-coated APZ-MMT has strong potential for the taste masking of APZ. Notably, in simulated gastric juice at pH 1.2, the total percentage of APZ that was released within the first 2 h increased up to 95 % for AEA-coated APZ-MMT. Furthermore, this in vitro release profile was also similar to that of Abilify, a com. available medication. In vivo experiments by using Sprague-Dawley rats were also performed to compare the pharmacokinetics of AEA-coated APZ-MMT and Abilify. AEA-coated APZ-MMT exhibited about 20 % higher systemic exposure of APZ and its metabolite, dehydro-APZ, compared with Abilify. Therefore, a new MMT-based nanovehicle, which is coated with a cationic polymer, can act as a promising delivery system for both taste masking and for enhancing the bioavailability of APZ. In the experiment, the researchers used many compounds, for example, 7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4Formula: C23H25Cl2N3O2).

7-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)quinolin-2(1H)-one (cas: 129722-25-4) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Formula: C23H25Cl2N3O2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

A miRNA Panel Predicts Sensitivity of FGFR Inhibitor in Lung Cancer Cell Lines was written by Ren, Shengxiang;Rivard, Christopher J.;Yu, Hui;Genova, Carlo;Rozenboom, Leslie;Gao, Dexiang;Hinz, Trista K.;Rikke, Brad A.;Wynes, Murry W.;Caldwell, Charles;Agustoni, Francesco;Kenichi suda;Jiang, Tao;Zhou, Caicun;Heasley, Lynn E.;Hirsch, Fred R.. And the article was included in Clinical Lung Cancer in 2018.Related Products of 1035270-39-3 This article mentions the following:

To test whether a microRNA (miRNA) panel may serve as an alternative biomarker of fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor sensitivity in lung cancer.Histol. diverse lung cancer cell lines were submitted to assays for ponatinib and AZD4547 sensitivity. miRNAs, FGFR1 mRNA, gene copy number, and protein expression were detected by real-time quant. PCR, fluorescence in-situ hybridization, and immunoblotting in 34 lung cancer cell lines.Among 34 cell lines, 14 exhibited ponatinib sensitivity and 20 exhibited AZD4547 sensitivity (drug concentration causing 50% inhibition values < 100 nmol/L). A total of 39 of the 377-miRNA set were initially identified from the 4 paired ponatinib-sensitive or -insensitive cell lines to have at least an 8-fold differential expression and then were detected in all the 34 cell lines. The miRNA panel performed similar to FGFR1 protein expression (AUC = 0.864) and mRNA expression (AUC = 0.939), and better than FGFR1 amplification (AUC = 0.696). Furthermore, we validated this panel using data for sensitivity to AZD4547 in the cell line cohort with an AUC of 0.931 and a sensitivity of 73.3% and specificity of 76.2%, resp.The developed miRNA panel (let-7c, miRNA155, and miRNA218) may be useful in predicting response to FGFR tyrosine kinase inhibitors, either ponatinib or AZD4547 in lung cancer cell lines, and warrants further validation in the clin. setting. In the experiment, the researchers used many compounds, for example, rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide (cas: 1035270-39-3Related Products of 1035270-39-3).

rel-N-(5-(3,5-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R,5S)-3,5-dimethylpiperazin-1-yl)benzamide (cas: 1035270-39-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Related Products of 1035270-39-3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics