Recent research progress on synthesis of hydroxyzine dihydrochloride was written by Zhong, Min;Peng, Xiaohai;Luo, Jin;You, Qingliang;Yu, Zongyuan. And the article was included in Huaxue Yu Shengwu Gongcheng in 2011.COA of Formula: C21H29Cl3N2O2 This article mentions the following:
Various synthetic routes of the first generation antihistamines, hydroxyzine dihydrochloride, and its key intermediate 2-(2-chloroethoxy) ethanol and the main ring 1-[(4-chlorophenyl) benzyl]-piperazine were summarized and commented. A suitable route for industrialization was selected as follows: hydroxyzine dihydrochloride was obtained through condensation of 2-(2-chloroethoxy) ethanol and 1-[(4-chlorophenyl) benzyl]-piperazine, acidification. In the experiment, the researchers used many compounds, for example, 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3COA of Formula: C21H29Cl3N2O2).
2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride (cas: 2192-20-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. COA of Formula: C21H29Cl3N2O2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics