Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA was written by Wang, Ming-Qi;Xu, Jing;Zhang, Lan;Liao, Yue;Wei, Heng;Yin, Ying-Ying;Liu, Qiang;Zhang, Yuan. And the article was included in Bioorganic & Medicinal Chemistry in 2019.Electric Literature of C12H16N2O This article mentions the following:
Selective and sensitive detection of G-quadruplex DNA structures is an important issue and attracts extensive interest. To this end, numerous small mol. fluorescent probes have been designed. Here, the authors present a series of N-alkylated styrylquinolinium dyes named Ls-1, Ls-2 and Ls-3 with varying side groups at the chain end. These dyes exhibited different binding behaviors to DNAs, and Ls-2 with a sulfonato group at the chain end displayed sensitivity and selectivity to G-quadruplex DNA structures in vitro. The characteristics of this dye and its interaction with G-quadruplex DNA were comprehensively studied by UV-visible spectrophotometry, fluorescence, CD and mol. docking. Furthermore, confocal fluorescence images and MTT assays indicated dye Ls-2 could pass through membrane and enter the living HepG2 cells with low cytotoxicity. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Electric Literature of C12H16N2O).
4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C12H16N2O
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics