Synthesis and biological screening of 1-N-[4-[bis((4-fluorophenyl)methyl]-1-piperazinyl]-4-arylidene-2-(4-methoxyphenyl)-5-oxoimidazolines was written by Savaliya, M. D.;Dobaria, J. G.;Bhuva, V. V.;Purohit, D. M.. And the article was included in Organic Chemistry: An Indian Journal in 2010.Quality Control of 4,4-Difluorobenzhydrylpiperazine This article mentions the following:
Several piperazine imidazolone derivatives were designed for a study of their antimicrobial activity, the synthesis of the target compounds was achieved by a reaction of 4-[bis(4-fluorophenyl)methyl]-1-piperazinamine with 2-(4-methoxyphenyl)-4-(arylmethylene)-5-oxazolone derivatives and the products thus obtained were confirmed by IR, 1H-NMR, MS, and elemental anal. The title compounds thus obtained [i.e., 3-[4-bis(4-fluorophenyl)methyl]-3,5-dihydro-2-(4-methoxyphenyl)-5-(arylmethylene)-4H-imidazol-4-one derivatives] were evaluated against Bacillus subtilis, Bacillus cereus, Escherichia coli, Enterobacter aerogenes, and Aspergillus niger and it was discovered that these compounds displayed moderate antimicrobial activity in comparison with ampicillin, chloramphenicol, norfloxacin, and griseofulvin at a concentration of 50 μg/mL. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Quality Control of 4,4-Difluorobenzhydrylpiperazine).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Quality Control of 4,4-Difluorobenzhydrylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics