Synthesis of new hexahydropyrimido[1,2-a]azepine derivatives bearing functionalized aryl and heterocyclic moieties as anti-inflammatory agents was written by Hassanein, Hassanein H.;Abdel Rahman, Doaa E.;Fouad, Marwa A.;Ahmed, Rehab F.. And the article was included in Future Medicinal Chemistry in 2021.HPLC of Formula: 27913-99-1 This article mentions the following:
New hexahydropyrimido[1,2-a]azepine derivatives bearing functionalized aryl and heterocyclic moieties were synthesized as anti-inflammatory agents with better safety profiles. All synthesized compounds were assessed in vitro for their COX-1 and COX-2 inhibition activities. The most selective compounds, 2f, 5 and 6, were further evaluated for their in vivo anti-inflammatory activity and PGE2 inhibitory activity. To rationalize their selectivity, mol. docking within COX-1 and COX-2 binding sites was performed. Their physicochem. properties and drug-like nature profile were also calculated The good activity and selectivity of compounds 2f, 5 and 6 were rationalized using a mol. docking study and supported by in vivo studies. These promising findings are encouraging for performing future investigations of these derivatives In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1HPLC of Formula: 27913-99-1).
4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.HPLC of Formula: 27913-99-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics