Synthesis, molecular docking and biological evaluation of metronidazole derivatives containing piperazine skeleton as potential antibacterial agents was written by Wang, She-Feng;Yin, Yong;Qiao, Fang;Wu, Xun;Sha, Shao;Zhang, Li;Zhu, Hai-Liang. And the article was included in Bioorganic & Medicinal Chemistry in 2014.Related Products of 27469-60-9 This article mentions the following:
Metronidazole has a broad-spectrum antibacterial activity. Hereby a series of novel metronidazole derivatives were designed and synthesized based on nitroimidazole scaffold in order to find some more potent antibacterial drugs. For these compounds which were reported for the first time, their antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus were tested. These compounds showed good antibacterial activities against Gram-pos. strains. One compound represented the most potent antibacterial activity against S. aureus ATCC 25923 with MIC of 0.003 渭g/mL and it showed the most potent activity against S. aureus TyrRS with IC50 of 0.0024 渭M. Mol. docking of one compound into S. aureus tyrosyl-tRNA synthetase active site were also performed to determine the probable binding mode. In the experiment, the researchers used many compounds, for example, 4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9Related Products of 27469-60-9).
4,4-Difluorobenzhydrylpiperazine (cas: 27469-60-9) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Related Products of 27469-60-9
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics