Discovery of a novel series of imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors was written by Shi, Chen;Wang, Qian;Liao, Xuemei;Ge, Hui;Huo, Guoyong;Zhang, Leduo;Chen, Na;Zhai, Xiong;Hong, Yuan;Wang, Li;Wang, Zhe;Shi, Weijun;Mao, Yu;Yu, Jianxin;Ke, Ying;Xia, Guangxin. And the article was included in European Journal of Medicinal Chemistry in 2020.Quality Control of tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate This article mentions the following:
CDK4/6 has been identified as an attractive therapeutic target for treatment of cancer. For unmet clin. needs, a novel class of imidazo [1′,2′:1,6]pyrido [2,3-d]pyrimidin derivatives, which had distinctive triheteroaryl structure, had been discovered as CDK4/6 inhibitors. The compounds 10b (I) and 10c (II), displayed the low nanomolar range activities on CDK4/6, desirable antiproliferative activities, excellent metabolic properties, and acceptable pharmacokinetic characters. In Colo-205 and U87MG xenograft models, compounds 10b and 10c also showed significant tumor growth inhibitions with controllable toxicities. All data confirmed that imidazo [1′,2′:1,6]pyrido [2,3-d]pyrimidin derivatives 10b and 10c could be promising drug candidates for cancer therapy. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate (cas: 304897-49-2Quality Control of tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate).
tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate (cas: 304897-49-2) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Quality Control of tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics