Synthesis and biological evaluation of benzopyran analogues bearing class III antiarrhythmic pharmacophores was written by Koufaki, Maria;Kiziridi, Christina;Papazafiri, Panagiota;Vassilopoulos, Athanasios;Varro, Andras;Nagy, Zsolt;Farkas, Attila;Makriyannis, Alexandros. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Formula: C11H13N3O3 This article mentions the following:
We have synthesized a series of compounds combining the hydroxy-benzopyran ring of vitamin E with the methylsulfonylaminophenyl group of class III antiarrhythmic drugs, connected through tertiary amine moieties. Evaluation of the antiarrhythmic and antioxidant activity of the new compounds was carried out on isolated rat heart preparations using the non-recirculating Langendorff mode. The new analogs were present, at 10 渭M concentration, during ischemia and reperfusion. Selected compounds were further studied by a conventional microelectrode method in order to get insight into their cellular mode of action. The most active compound, N-[4-[2-[[2-(3,4-dihydro-6-hydroxy-2,2,7,8-tetramethyl-2H-1-benzopyran-5-yl)ethyl] methylamine]ethyl]phenyl]methanesulfonamide (19a, I), reduces premature beats, prolongs QT and QRS intervals during ischemia and reperfusion, and reduces MDA content, leading to a fast recovery of the heart. In addition, it exhibits moderate class III antiarrhythmic action. In the experiment, the researchers used many compounds, for example, (4-Nitrophenyl)(piperazin-1-yl)methanone (cas: 72141-41-4Formula: C11H13N3O3).
(4-Nitrophenyl)(piperazin-1-yl)methanone (cas: 72141-41-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C11H13N3O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics