Efficient synthesis of a new class of N-nucleosides of 4H-thiochromeno[2,3-d]pyrimidine-10-sulfone as potential anticancer and antibacterial agents was written by Alshammari, Abdulrahman G.;El-Gazzar, Abdel-Rhman B. A.;Hafez, Hend N.. And the article was included in International Journal of Organic Chemistry in 2013.Product Details of 27913-99-1 This article mentions the following:
A highly practical and efficient preparation of 6-methyl-4H-thiochromene and 7-methyl-thiochromene[2,3-d]pyrimidine derivatives, e.g. I (X = NH, NMe, O), was developed via a multi-component reaction of 3-methyl-thiophenol, aldehydes, and malononitrile. A series of pyrimidine nucleoside, thiochromene[2,3-d]pyrimidine and thiochromene[2,3-d]pyrimidine-10-sulfone was efficiently obtained. These hybrid compounds were evaluated as potential antibacterial and anticancer agents and showed encouraging biol. activities. Some of these derivatives showed broad-spectrum antitumor activity against the nine tumor sub-panels tested, and demonstrated significant activity in the in vitro antitumor screening expressed by MG-MID log10GI50 value of -4.55, -4.67 and -4.73 of compounds I (X = NH, NMe, O), resp. In the experiment, the researchers used many compounds, for example, 4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1Product Details of 27913-99-1).
4-(4-Methylpiperazin-1-yl)benzaldehyde (cas: 27913-99-1) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Product Details of 27913-99-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics