Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists was written by Walczynski, Krzysztof;Zuiderveld, Obbe P.;Timmerman, Henk. And the article was included in European Journal of Medicinal Chemistry in 2005.Safety of 1-Propylpiperazine This article mentions the following:
Propylpiperazinyl benzoxazoles, benzothiazoles, oxazolopyridines, and thiazolopyridines I [X = O, S; Y, Z, A, B = CH, N (either none or one of the variable groups is N)] and their hydrobromide salts are prepared as selective histamine H3 receptor antagonists; their histamine H3 antagonist activities and the relationship between their structures and activities are discussed. Propylpiperazinyl-substituted thiazolopyridines and a propylpiperazinyl-substituted benzothiazole are better histamine H3 antagonists than propylpiperazinyl-substituted oxazolopyridines and a propylpiperazinyl-substituted benzooxazole. I (X = S; Y = A = B = CH; Z = N) is the most potent histamine H3 antagonist of the series, with a pA2 value of 7.25, while the corresponding oxazolopyridine I (X = O; Y = A = B = CH; Z = N) has a pA2 value of 6.9. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Safety of 1-Propylpiperazine).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Safety of 1-Propylpiperazine
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics