Jung, Myung-Ho et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2012 | CAS: 630125-91-6

4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Synthetic Route of C14H20F3N3

Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines. Part 2 was written by Jung, Myung-Ho;El-Gamal, Mohammed I.;Abdel-Maksoud, Mohammed S.;Sim, Taebo;Yoo, Kyung Ho;Oh, Chang-Hyun. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Synthetic Route of C14H20F3N3 This article mentions the following:

A new series of 16 diarylureas and diarylamides possessing the 1H-pyrrolo[3,2-c]pyridine scaffold was designed and synthesized. Their in vitro antiproliferative activities against A375P human melanoma cell line and NCI-9 human melanoma cell line panel were tested. All the target compounds, except three amino derivatives demonstrated superior potencies against A375P to Sorafenib. In addition, 6 compounds demonstrated higher potencies than Vemurafenib against A375P. Two compounds were 7.50 and 454.90 times, resp., more selective towards A375P melanoma cells over NIH3T3 fibroblasts. Furthermore, 7 compounds demonstrated very high potencies against the nine tested melanoma cell lines at the NCI. Of the bisamide derivatives, 4 showed 2-digit nanomolar IC50 values over different cell lines of the NCI-9 melanoma cell lines and 1 of these, I, is a promising lead for a new selective anticancer agent for treatment of melanoma.. In the experiment, the researchers used many compounds, for example, 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6Synthetic Route of C14H20F3N3).

4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (cas: 630125-91-6) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Synthetic Route of C14H20F3N3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics