Design and synthesis of novel antifungal triazole derivatives with good activity and water solubility was written by Cao, Xu-Feng;Chu, Wen-Jing;Cao, Yong-Bing;Yang, Yu-She. And the article was included in Chinese Chemical Letters in 2013.Product Details of 119285-07-3 This article mentions the following:
To find novel antifungal agents with good activity and aqueous solubility, a series of SYN-2869 analogs containing a pyridine ring were synthesized and were evaluated for their in vitro antifungal activity and water-solubility Some of the compounds showed potent activity against pathogenic fungi. In particular, an analog having an iso-Bu substitution on the triazolone exhibited significant broad spectrum antifungal activity. In addition, the water solubility of this compound was sufficiently improved over SYN-2869. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3Product Details of 119285-07-3).
tert-Butyl 4-(5-aminopyridin-2-yl)piperazine-1-carboxylate (cas: 119285-07-3) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Product Details of 119285-07-3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics