Combinatorial synthesis of 3-substituted 5-aminoisoxazole-4-carboxamides was written by Alyab’ev, S. B.;Kravchenko, D. V.;Dorogov, M. V.;Ivashchenko, A. V.. And the article was included in Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya in 2007.Reference of 611225-86-6 This article mentions the following:
The combinatorial library of novel 3-substituted 5-aminoisoxazole-4-carboxamides I (R1 = Ph, 2-FC6H4, 4-F3CC6H4, 4-ClC6H4, etc.; R2 = 1-imidazolyl, 4-EtC6H4NH, 2-Me-3-ClC6H3NH, etc.; R3 = 1-pyrrolidinyl, 1-piperidinyl, 4-morpholinyl, azepan-1-yl) was prepared using a parallel synthesis approach. The target compounds were obtained by alk. hydrolysis of the esters I (R2 = OMe) followed by treatment with POCl3 and amination with secondary amines in the presence of Et3N in dioxane. The esters I (R2 = OMe) were in turn prepared from the corresponding Me 3-aryl-5-hydroxy-4-isoxazolecarboxylates by chlorination with POCl3 followed by amination with secondary cyclic amines R3H. In the experiment, the researchers used many compounds, for example, 4-(4-Ethylpiperazin-1-ylmethyl)phenylamine (cas: 611225-86-6Reference of 611225-86-6).
4-(4-Ethylpiperazin-1-ylmethyl)phenylamine (cas: 611225-86-6) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Reference of 611225-86-6
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics