Synthesis of pyrido[3,4-d]pyrimidines by condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine was written by Kuznetsov, A. Yu.;Nam, N. L.;Chapyshev, S. V.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2007.COA of Formula: C7H16N2 This article mentions the following:
A method has been developed for the synthesis of 4-amino-substituted tetrahydropyridopyrimidines, e.g., I, by condensation of Et 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine followed by sulfonylation with trifluoromethanesulfonic anhydride and amination with secondary amines. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1COA of Formula: C7H16N2).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.COA of Formula: C7H16N2
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics