New piperazine amidines and related compounds. Potential antihypertensives and diuretics was written by Areschka, Alex;Mahaux, Jean;Verbruggen, Francis;Houben, Christian;Descamps, Marcel;Heyndrickx, Jean P.;Beersaerts, Joseph;Colot, Michel;Charlier, Robert. And the article was included in European Journal of Medicinal Chemistry in 1976.Product Details of 21867-64-1 This article mentions the following:
Amidines I (R = 2-ethyl-3-benzothienyl, 2-butyl-3-benzothienyl, 2-methyl-3-benzothienyl, 3-methyl-5-chloro-2-benzothienyl, Ph, 2-ClC6H4, 4-ClC6H4, 4-MeOC6H4, 2-benzodioxanyl, H, Me, Et; R1 = Me, Et, Pr, 2-pyridyl, 4-pyridyl, H, CHMe2, Bu, 4-ClC6H4, 4-FC6H4, 3-F3CC6H4, CH2Ph) and II [X = CH2, CHMe, CHOH, O, (CH2)3, CH2NMe] were prepared by ethanolysis of RCH2CN and aminolysis of the product RCH2C(:NH)OEt. Some I and II displayed diuretic and antihypertensive activity in animal tests, which were not observed in clinical tests, however. In the experiment, the researchers used many compounds, for example, 1-Propylpiperazine (cas: 21867-64-1Product Details of 21867-64-1).
1-Propylpiperazine (cas: 21867-64-1) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Product Details of 21867-64-1
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics