Month: November 2022

Onida, Killian published the artcileDirect Synthesis of Carbamoyl Fluorides by CO₂ Deoxyfluorination, Category: piperazines, the publication is Angewandte Chemie, International Edition (2019), 58(36), 12545-12548, database is CAplus and MEDLINE.

Herein, a new concept for the direct synthesis of carbamoyl fluoride derivatives is disclosed. The developed method makes use of CO₂ as an inexpensive and abundant C₁ source; a variety of amines were successfully converted in the presence of a deoxyfluorinating reagent. The corresponding products were often obtained in excellent yields under mild reaction conditions (1 atm and room temperature). The reaction was easily scaled up, demonstrating the efficiency of the developed process.

Angewandte Chemie, International Edition published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Category: piperazines.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Chen, Peng-Jen published the artcileDesign, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D₃ receptor ligands, Safety of 1-(3-Cyanophenyl)piperazine, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(18), 2690-2694, database is CAplus and MEDLINE.

As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a identified a series of N-(4-(4-Ph piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide D₃ ligands. Members of this class are highly selective for D₃ vs. D₂, and we have identified two compounds (13g and 13r) whose rat in vivo IV pharmacokinetic properties that indicate that they are suitable for assessment in in vivo efficacy models of substance use disorders.

Bioorganic & Medicinal Chemistry Letters published new progress about 178928-58-0. 178928-58-0 belongs to piperazines, auxiliary class Piperazine,Nitrile,Benzene, name is 1-(3-Cyanophenyl)piperazine, and the molecular formula is C11H13N3, Safety of 1-(3-Cyanophenyl)piperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Ruan, Banfeng published the artcileSynthesis and Biological Evaluation of Novel Phthalide Analogs-1,2,4-Oxadiazole Hybrids as Potential Anti-Inflammatory Agents, Formula: C10H17N3O2, the publication is Chemistry & Biodiversity (2022), 19(8), e202200039, database is CAplus and MEDLINE.

A series of novel pathalide-1,2,4-oxadiazole analogs were synthesized for discovering novel anti-inflammatory agents. After the assessment of their cytotoxicity in vitro, all compounds had been screened for their anti-inflammatory activity by evaluating their inhibitory effect on LPS-induced NO production in RAW 264.7 macrophages. SARs had been concluded, and finally compound E13 was found to be the most potent compound This compound could also significantly decrease the production of iNOS and COX-2. Preliminary mechanism studies indicated that compound E13 could inhibit the TLR4/NF-κB and ERK/p38 signaling pathways. These findings indicate that E13 holds great potential to be a lead compound for discovering novel anti-inflammatory drugs.

Chemistry & Biodiversity published new progress about 113534-02-4. 113534-02-4 belongs to piperazines, auxiliary class Piperazine,Nitrile,Amide, name is tert-Butyl 4-cyanopiperazine-1-carboxylate, and the molecular formula is C10H17N3O2, Formula: C10H17N3O2.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Pettersson, Fredrik published the artcileSynthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines, Recommanded Product: 1-(3-Cyanophenyl)piperazine, the publication is European Journal of Medicinal Chemistry (2013), 241-255, database is CAplus and MEDLINE.

A series of mono-substituted 4-phenylpiperidines and -piperazines have been synthesized and their effects on the dopaminergic system tested in vivo. The structure activity relationship (SAR) revealed that the position and physicochem. character of the aromatic substituent proved to be critical for the levels of 3,4-dihydroxyphenylacetic acid (DOPAC) in the brain of freely moving rats. In order to investigate how the structural properties of these compounds affect the response, a set of tabulated and calculated physicochem. descriptors were modeled against the in vivo effects using partial least square (PLS) regression. Furthermore, the binding affinities to the dopamine D₂ (DA D₂) receptor and monoamine oxidase A (MAO A) enzyme were determined for a chosen subset and QSAR models using the same descriptors as in the in vivo model were produced to investigate the mechanisms leading to the observed DOPAC response. These models, in combination with a strong correlation between the levels of striatal DOPAC and the affinities to DA D₂ and MAO A, provide a comprehensive understanding of the biol. response for compounds in this class.

European Journal of Medicinal Chemistry published new progress about 178928-58-0. 178928-58-0 belongs to piperazines, auxiliary class Piperazine,Nitrile,Benzene, name is 1-(3-Cyanophenyl)piperazine, and the molecular formula is C11H13N3, Recommanded Product: 1-(3-Cyanophenyl)piperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Srikanth Reddy, T. published the artcileSemi-synthesis and bio-evaluation of polybrominated diphenyl ethers from the sponge Dysidea herbacea, Recommanded Product: (E)-1-Cinnamylpiperazine, the publication is Bioorganic & Medicinal Chemistry Letters (2012), 22(14), 4900-4906, database is CAplus and MEDLINE.

The sponge Dysidea herbacea was collected from the Mandapam Coast, Tamilnadu, India. Isolated gram quantities of hydroxylated polybrominated di-Ph ether (HO-PBDE) and semi-synthesized a series of new PBDEs derivatives and tested them for antibacterial and cytotoxic activities.

Bioorganic & Medicinal Chemistry Letters published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C22H21N3O3S, Recommanded Product: (E)-1-Cinnamylpiperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Sodeifian, Gholamhossein published the artcileSolubility of Dasatinib monohydrate (anticancer drug) in supercritical CO₂: Experimental and thermodynamic modeling, Application of N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate, the publication is Journal of Molecular Liquids (2022), 117899, database is CAplus.

Solubility of Dasatinib monohydrate (DAS, an anticancer drug) in supercritical carbon dioxide (Sc-CO₂) was examined statically at temperatures ranging from 308 to 338 K and pressures ranging from 120 to 270 bar. Based on the results, mole fractions of DAS dissolved in the Sc-CO₂ were reported as 0.45 x 10^-6 to 9.08 x 10^-6, leading to solubilities in the range of 0.004-0.082 g/L, resp. The exptl. data were correlated using three types of models: (1) 20 existing empirical and semi-empirical models including 3-6 parameters on the basis of functional dependencies, (2) temperature-dependent and temperature-independent variants of the Peng-Robinson’s (PR) cubic equation of state with a conventional mixing rule, and (3) solid-liquid equilibrium models. All tested models could produce appropriate fits to the solubility data at acceptable levels of accuracy, although solid-liquid equilibrium models led to the superiority based on AARD and AICc criterion. Furthermore, solvation and sublimation enthalpies were estimated

Journal of Molecular Liquids published new progress about 863127-77-9. 863127-77-9 belongs to piperazines, auxiliary class TGF-beta/Smad,Bcr-Abl,Natural product, name is N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate, and the molecular formula is C12H14IN, Application of N-(2-Chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide hydrate.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Chan, Kin-Fai published the artcileEfficient Synthesis of Amine-Linked 2,4,6-Trisubstituted Pyrimidines as a New Class of Bacterial FtsZ Inhibitors, Quality Control of 87179-40-6, the publication is ACS Omega (2017), 2(10), 7281-7292, database is CAplus and MEDLINE.

We have recently identified a new class of FtsZ-interacting compounds that possess a 2,4,6-trisubstituted pyrimidine-quinuclidine scaffold with moderate antibacterial activity. Employing this scaffold as a mol. template, a compound library of amine-linked 2,4,6-trisubstituted pyrimidines with ninety-nine candidates was successfully established by employing an efficient convergent synthesis designed to explore its structure activity relationship. The results of min. inhibitory concentration (MIC) assay against S. aureus strains and cytotoxicity assay against mouse L929 cell line identified those compounds with potent anti-staphylococcal properties (MIC ranges from 3 to 8 μg/mL) and some extent of cytotoxicity against normal cell (IC₅₀ ranges from 6 to 27 μM). Importantly, three compounds also exhibited potent antibacterial activities against nine clin. isolated MRSA strains. One of the compounds, I, exhibited low spontaneous frequency of resistance, low toxicity against G. mellonella larvae as well as the ability to rescue G. mellonella larvae (20% survival rate at dosage of 100 mg/Kg) infected with LD of MRSA ATCC 43300 strain. Biol. characterization of compound I by saturation transfer difference NMR, light scattering assay and GTPase hydrolysis assay with purified S. aureus FtsZ protein verified that it interacted with the FtsZ protein. Such property of FtsZ inhibitor was further confirmed by observations of iconic filamentous cell phenotype and mislocalization of the Z-ring formation of B. subtilis. Taken together, these 2,4,6-trisubstituted pyrimidine derivatives represent a novel scaffold of S. aureus FtsZ inhibitors.

ACS Omega published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Quality Control of 87179-40-6.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Takeuchi, Isao published the artcileSyntheses and antimicrobial activities of cis-1-[2-phenyl-4-(phenoxy or phenylthio)methyl-1,3-dioxolan-2-ylmethyl]-1H-imidazole derivatives, SDS of cas: 67914-60-7, the publication is Yakugaku Zasshi (1985), 105(6), 554-61, database is CAplus and MEDLINE.

Substitution reactions of glycerol ketals I (R, R¹ = H, MeO; Br, Br; Cl, Cl) with heterocycles gave II (R² = 1-imidazolyl, 1-pyrazolyl, 1,2,4-triazol-1-yl) which underwent successive saponification, mesylation, and substitution reaction with R³R⁴C₆H₃XH (R³, R⁴ = H, MeO, Cl, Me, Br; X = O, S) to give ketoconazole analogs III. Antimicrobial test of the synthesized compounds III (R² = 1-imidazolyl; R, R¹, R³, R⁴, X = Cl, Cl, H, 4-Cl, S; Cl, Cl, 2-Cl, 6-Cl, S; Br, Br, 2-Cl, 6-Cl, S) showed strong antimicrobial activities against Penicillium chrysogenum and Trichophyton rubrum. Most compounds synthesized had strong preventive effects against downy mildew and sheath blight. Triazole derivatives III (R² = 1-triazolyl; R = R¹ = Cl; R³ = H, 2-Cl; R⁴ = Cl; X = S, O) showed similar effects against not only such diseases but gray mold rot.

Yakugaku Zasshi published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C38H74Cl2N2O4, SDS of cas: 67914-60-7.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Corsano, Stefano published the artcileSynthesis and pharmacological evaluation of some analogs of the calcium-antagonist cinnarizine, Recommanded Product: (E)-1-Cinnamylpiperazine, the publication is Archiv der Pharmazie (Weinheim, Germany) (1988), 321(3), 171-4, database is CAplus and MEDLINE.

Title compounds, e.g. I, II, and Ph₂CHNHCH₂CH₂OC₆H₃(OMe)₂-2,6, were prepared Thus, 1-benzhydrylpiperazine was treated with o-MeOC₆H₄OCH₂CH₂Br to give I. The new compounds had lower Ca antagonist activity than cinnarizine.

Archiv der Pharmazie (Weinheim, Germany) published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Recommanded Product: (E)-1-Cinnamylpiperazine.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics

Nadigar, Mohan R. published the artcileSynthesis and in vitro antibacterial activity of some novel sulfonamide derivatives bearing 1,4-disubstituted-1,2,4-oxadiazole moiety, SDS of cas: 113534-02-4, the publication is Journal of Applicable Chemistry (Lumami, India) (2013), 2(4), 722-729, database is CAplus.

A strategic synthesis of 1-[(2,5-dimethoxyphenyl)sulfonyl]-4-{5-[substituted]-1,2,4-oxadiazol-3-yl}piperazine, involves construction of 1,2,4-oxadiazole ring by intermol. condensation of tert-butyl-4-(N-hydroxycarbamimidoyl)piperazine-1-carboxylate with 3-(trifluromethoxy)benzoic acid. Structures of the newly synthesized compounds were established by IR, ¹H NMR, ¹³C NMR, LC-MS and CHNS spectroscopic evidences. All the newly synthesized compounds were tested for their in vitro antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus cereus. Tested compounds showed good antibacterial activities when compared to the reference ciprofloxacin. Five compounds showed good activity against tested organisms.

Journal of Applicable Chemistry (Lumami, India) published new progress about 113534-02-4. 113534-02-4 belongs to piperazines, auxiliary class Piperazine,Nitrile,Amide, name is tert-Butyl 4-cyanopiperazine-1-carboxylate, and the molecular formula is C10H17N3O2, SDS of cas: 113534-02-4.

Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics