Month: November 2022

A novel amorphous porous biochar for adsorption of antibiotics: Adsorption mechanism analysis via experiment coupled with theoretical calculations was written by Zhang, Yang;Cheng, Long;Ji, Yuanhui. And the article was included in Chemical Engineering Research and Design in 2022.Synthetic Route of C16H18FN3O3 The following contents are mentioned in the article:

High-performance activated carbons are crucial for adsorbing antibiotics in water environment. In this work, amorphous porous biochars (APBCs) with high sp. surface area (935 m²·g^-1) were achieved by using sesame straw. Compared with the conventional biochars precursor, sesame straw with the advantages of rich resources and low price is more economical and environmentally friendly. Moreover, KOH and Ca(OH)2 were selected as co-activators, which characterization results revealed that co-activators significantly increased the coarseness of activated carbon surface and enlarged pore structure. In addition, the adsorption mechanism of norfloxacin (NOR), ciprofloxacin (CIP) and enrofloxacin (ENR) on APBCs were further investigated by experiments and d. functional theory (DFT) calculations The results discovered that pseudo second-order kinetics and Sips model followed the adsorption experiment data, implying that the adsorption process was heterogeneous and multilayer. And the interactions between APBCs and antibiotics were electrostatic interaction, hydrogen bond and π-π interaction, which were conducive to chem. adsorption. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Synthetic Route of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Synthetic Route of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Enhanced ratiometric fluorescence molecularly imprinted nanosensor based on CDs for selective and visual detection of NOR in water samples was written by Wu, Tongfei;Hu, Bo;Lv, Jie;Li, Yunhui;Shao, Jing;Ma, Yuqin;Cui, Yuan. And the article was included in Optical Materials (Amsterdam, Netherlands) in 2022.Category: piperazines The following contents are mentioned in the article:

Norfloxacin plays an indispensable part in the field of the medical industry, stock raising, and aquaculture. However, excessive use of NOR can induce serious harmful effects on humans and antibiotic resistance of organisms. In this work, a novel fluorescence-enhanced ratiometric fluorescence imprinted sensor was constructed and used to realize selective and accurate detection of NOR. CdTe quantum dots encapsulated in silicon dioxide acted as the reference signal and CDs doped in the imprinted layer as the response signal. Under optimal conditions, NOR rapidly enhanced the fluorescence of CdTe@SiO₂@FMIPs at 435 nm with 1 min and exhibited excellent linear relationships between the fluorescence enhancement efficiency and the NOR concentration over 10-90 nM with a detection limit of 3.28 nM. Due to the interaction of NOR and CDs through hydrogen bonding as well as π-π conjugation, the visual detection for NOR was achieved by distinguishing the color change from red to bright blue. Satisfied recovery rates of 93.4%-107.7% and RSD of 2.0%-3.6% were gained by actual sample experiments Furthermore, CdTe@SiO₂@FMIPs made it possible to reuse at least 5 times. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for specific recognition and determination of chloramphenicol in milk was written by Geng, Lingjun;Huang, Jingcheng;Zhai, Hongguo;Shen, Zheng;Han, Jie;Yu, Yanyang;Fang, Honggang;Li, Falan;Sun, Xia;Guo, Yemin. And the article was included in Microchemical Journal in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

A molecularly imprinted electrochem. sensor of chloramphenicol (CAP) with high sensitivity and good selectivity is introduced in this paper. Glassy carbon electrode (GCE) was modified by chitosan-multiwalled carbon nanotubes (CS-MWCNTs), the CS could improve the dispersion of MWCNTS, and the MWCNTS could significantly improve the current response of the sensor, thus improving the sensitivity. CAP was used as a template mol. and o-phenylenediamine (o-PD) was used as a functional monomer, resp. Molecularly imprinted polymers (MIPs) were prepared on the surface of a GCE modified with CS-MWCNTs by electro-polymerization The MIPs provided specific recognition sites for the detection of chloramphenicol. The exptl. parameters such as polymerization cycle, concentration ratio of template mol. to functional monomer, supporting electrolyte pH and incubation time were optimized. Under optimized exptl. conditions, the sensor has a linear range of 0.1-1000 ng/mL and the limit of detection (LOD) of 3.3 x 10-2 ng/mL (S/N = 3). The sensor had high selectivity, good stability and reproducibility for the detection of CAP, and it has been successfully used for the determination of CAP in real spiked milk samples. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Biosynthesis of zinc oxide nanoparticles via endophyte Trichodermaviride and evaluation of their antimicrobial and antioxidant properties was written by Kaur, Tanvir;Bala, Manju;Kumar, Gaurav;Vyas, Ashish. And the article was included in Archives of Microbiology in 2022.COA of Formula: C16H18FN3O3 The following contents are mentioned in the article:

The biogenic method for synthesis of nanoparticles is preferred over the traditional strategies, on account of its ease, environmental friendliness, and cost-effectivity, wherein fungi endorse themselves to be the most appropriate precursor for the same. In recent times numerous metal nanoparticles have been reported to exhibit significant therapeutic activities, out of which Zinc Oxide nanoparticles (ZnO NPs) stand apart on account of their multidimensional nature. Thus, this study was carried out with an aim to biosynthesize ZnO NPs utilizing endophyte Trichoderma viride, isolated from the seeds of Momordica charantia. The physicochem. characterization of NPs was done via employing a combination of spectroscopic and microscopic techniques. The NPs were found to have a hexagonal shape and possessed an average particle size of around 63.3 nm. The antimicrobial activity of NPs was evaluated against multi-drug resistant organisms and it was observed to be an appreciable one whereas the antioxidant activity was deduced to be dose-dependent. Thus, these ZnO NPs can be considered as a probable active ingredient of any future therapeutic conceptualization after undertaking a thorough toxicol. assessment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7COA of Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. COA of Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Property space mapping of Pseudomonas aeruginosa permeability to small molecules was written by Leus, Inga V.;Weeks, Jon W.;Bonifay, Vincent;Shen, Yue;Yang, Liang;Cooper, Connor J.;Nash, Dinesh;Duerfeldt, Adam S.;Smith, Jeremy C.;Parks, Jerry M.;Rybenkov, Valentin V.;Zgurskaya, Helen I.. And the article was included in Scientific Reports in 2022.Category: piperazines The following contents are mentioned in the article:

Two membrane cell envelopes act as selective permeability barriers in Gram-neg. bacteria, protecting cells against antibiotics and other small mols. Significant efforts are being directed toward understanding how small mols. permeate these barriers. In this study, we developed an approach to analyze the permeation of compounds into Gram-neg. bacteria and applied it to Pseudomonas aeruginosa, an important human pathogen notorious for resistance to multiple antibiotics. The approach uses mass spectrometric measurements of accumulation of a library of structurally diverse compounds in four isogenic strains of P. aeruginosa with varied permeability barriers. We further developed a machine learning algorithm that generates a deterministic classification model with minimal synonymity between the descriptors. This model predicted good permeators into P. aeruginosa with an accuracy of 89% and precision above 58%. The good permeators are broadly distributed in the property space and can be mapped to six distinct regions representing diverse chem. scaffolds. We posit that this approach can be used for more detailed mapping of the property space and for rational design of compounds with high Gram-neg. permeability. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Determination of quinolone antibiotics in environmental water using automatic solid-phase extraction and isotope dilution ultra-performance liquid chromatography tandem mass spectrometry was written by Zhu, Yingjie;He, Pengfei;Hu, Hongmei;Qi, Mengyu;Li, Tiejun;Zhang, Xiaoning;Guo, Yuanming;Wu, Wenyan;Lan, Qingping;Yang, Cancan;Jin, Hangbiao. And the article was included in Journal of Chromatography B in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

The widespread use of quinolones in humans and animals has become a major threat to public health. In this study, a simple, rapid, sensitive, and high throughput method based on automatic solid-phase extraction and isotope dilution ultra-performance liquid chromatog. tandem mass spectrometry was described for the determination of trace quinolones in environmental water. The proposed automated solid-phase extraction method was initially optimized, and the optimum exptl. conditions found were 1 L water sample with 0.5 g/L Na2EDTA (pH 3) extracted and enriched by CNW Poly-Sery HLB cartridge at a flow rate of 50 mL/min and eluted by 8 mL of methanol. The linearity of the method ranged from 0.05 to 100μg/L for 15 quinolones, with correlation coefficients ranging from 0.9993 to 0.9999. The limits of detection were in the low ng/L level, ranging from 0.005 to 0.051 ng/L. Finally, the optimized method was applied for determining trace levels of 15 quinolones in Wahaha pure water, tap water, river water, and seawater samples with good recoveries of 93%-119% and satisfactory relative standard deviations of 0.1%-13.9%. Fourteen quinolones were detected, and ofloxacin was the predominant congener in river water and seawater. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Contamination, transport, and ecological risks of pharmaceuticals and personal care products in a large irrigation region was written by Wang, Cong;Lu, Yonglong;Sun, Bin;Zhang, Meng;Wang, Rui;Li, Xiaoqian;Mao, Ruoyu;Cao, Zhiwei;Song, Shuai. And the article was included in Science of the Total Environment in 2022.Electric Literature of C16H18FN3O3 The following contents are mentioned in the article:

Pharmaceuticals and personal care products (PPCPs) have attracted widespread attention owing to their extensive use and potential adverse effects on human and ecosystem health. There is a lack of information regarding the occurrence and environmental fate of PPCPs in large agricultural irrigation areas in China. In this study, we conducted a comprehensive survey on 30 PPCPs in water from Hetao Irrigation District, one of the three largest irrigation areas in China. The ΣPPCP-concentrations ranged 82.13-1409.24 ng/L in August and 40.53-887.20 ng/L in Nov., with caffeine (CAF), norfloxacin (NOR), erythromycin (ERY), sulfamethoxazole (SMX) and ofloxacin (OFL) being the predominant compositions Spatially, the average ΣPPCP concentrations increased from irrigation to drainage water, and then decreased in Wuliangsuhai Lake. Less PPCP mass loading (55.05 kg/y) migrated from Wuliangsuhai Lake to Yellow River than that from the Yellow River to Hetao Irrigation District (425.88 kg/y), indicating that Wuliangsuhai Lake plays an important role in improving water quality. An ecol. risk assessment showed that it is worthwhile to consider the presence of CAF, ERY, NOR, and OFL in natural surface water and to control their potential risks. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Electric Literature of C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Electric Literature of C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Cobalt/calcium bimetallic oxides based on bio-waste eggshells for the efficient degradation of norfloxacin by peroxymonosulfate activation was written by Zhang, Xinyi;Yang, Zhiquan;Cui, Xiandi;Liu, Wanhui;Zou, Baosheng;Liao, Wenning. And the article was included in Journal of Colloid and Interface Science in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Cobalt-calcium bimetallic oxide (ECCO) was successfully prepared using eggshells and cobalt nitrate, which could be used to activate peroxymonosulfate (PMS) to remove norfloxacin (NOR). The compositional structure and surface properties of the catalysts were explored by various characterization anal. The degradation efficiency of ECCO was 7.86 and 440 times higher than that of cobalt oxide and calcium oxide, resp. The prepared ECCO (0.1 g/L) had a high degradation efficiency of over 90% against NOR (10 mg/L, 100 mL) by activating the PMS (0.15 g/L) at a wide pH range of 3.0-9.0 in 35 min. With a NOR removal efficiency of 91.4% after five cycles, the catalyst showed good reusability. The high degradation efficiency of NOR was resulted from enhanced electron transfer capability, the low point of zero charge and diversified reactive oxygen species (ROS). The ROS were identified as SO₄^•-, •OH and ¹O₂, which were produced by activating PMS on the active sites of Co and oxygen vacancies. It is the first report of the use of eggshells to synthesize cobalt-calcium bimetallic oxides ECCO for the activation of PMS to eliminate NOR, which is important for the development of green and efficient catalysts. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Enhanced photo-fenton and photoelectrochemical activities in nitrogen doped brownmillerite KBiFe₂O₅ was written by Vavilapalli, Durga Sankar;Behara, Santosh;Peri, Raja Gopal;Thomas, Tiju;Muthuraaman, B.;Rao, M. S. Ramachandra;Singh, Shubra. And the article was included in Scientific Reports in 2022.Application of 70458-96-7 The following contents are mentioned in the article:

Visible-light-driven photo-fenton-like catalytic activity and photoelectrochem. (PEC) performance of nitrogen-doped brownmillerite KBiFe₂O₅ (KBFO) are investigated. The effective optical bandgap of KBFO reduces from 1.67 to 1.60 eV post N-doping, enabling both enhancement of visible light absorption and photoactivity. The photo-fenton activity of KBFO and N-doped KBFO samples were analyzed by degrading effluents like Methylene Blue (MB), Bisphenol-A (BPA) and antibiotics such as Norfloxacin (NOX) and Doxycycline (DOX). 20 mmol of Nitrogen-doped KBFO (20N-KBFO) exhibits enhanced catalytic activity while degrading MB. 20N-KBFO sample is further tested for degradation of Bisphenol-A and antibiotics in the presence of H₂O₂ and chelating agent L-cysteine. Under optimum conditions, MB, BPA, and NOX, and DOX are degraded by 99.5% (0.042 min^-1), 83% (0.016 min^-1), 72% (0.011 min^-1) and 95% (0.026 min^-1) of its initial concentration resp. Photocurrent d. of 20N-KBFO improves to 8.83 mA/cm² from 4.31 mA/cm² for pure KBFO. Photocatalytic and photoelectrochem. (PEC) properties of N-doped KBFO make it a promising candidate for energy and environmental applications. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Application of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Application of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Norfloxacin adsorption and subsequent degradation on ball-milling tailored N-doped biochar was written by Wu, Jingqi;Wang, Tongshuai;Liu, Yuyan;Tang, Wei;Geng, Shuyu;Chen, Jiawei. And the article was included in Chemosphere in 2022.Reference of 70458-96-7 The following contents are mentioned in the article:

N-doping is an effective way to modify biochar for enhancing the adsorption capacity. The synthesis of N-doped biochar by the ball-milling method has been attractive due to its facile and eco-friendly approach with low energy consumption. However, the commonly used N-precursor NH₃·H₂O is environmentally harmful. It is needed to prepare safe and non-toxic N-doped biochar for large-scale production Here, a urea N-doped biochar (U-MBC) was prepared by the ball-milling method and used for norfloxacin (NOR) removal. The results showed that U-MBC exhibited almost 4-fold higher adsorption capacity for NOR than pristine biochar in a wide pH range (3-9). The adsorption enhancement was owing to the enhancement of H-bonds, π-π electron donor-acceptor, and pore-filling interactions due to the N-doping and ball-milling method. Addnl., 89% of adsorbed NOR can be further removed after 6 h milling. The regenerated U-MBC still had a good adsorption capacity (46.27 mg g^-1) and performed well in three cycles. The knowledge gained from this study could encourage researchers to use urea or similar safe N-precursors with the ball-milling method for the large-scale production of N-doped biochar to remove antibiotic organic pollutants in the environment. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Reference of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Reference of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics