Month: November 2022

Development and evaluation of cost effective formula of nintedanib esylate soft gelatin capsule and compare with prepared product similar to innovator was written by Gaikwad, Sonal S.;Singh, Meera C.. And the article was included in Research & Reviews: A Journal of Pharmaceutical Science in 2018.HPLC of Formula: 656247-18-6 The following contents are mentioned in the article:

Nintedanib esylate was invented by Boehringer Ingelheim Pharmaceuticals. Nintedanib esylate is an organosulfonate salt obtained by combination of Nintedanib with ethane sulfonic acid. It’s a kinase inhibitor used for the treatment of idiopathic pulmonary fibrosis and non-small cell lung cancer. Bioavailability and water solubility of Nintedanib esylate is very low and BCS class is not mentioned in the literature. Due to poor solubility of Nintedanib esylate at neutral conditions, the active substance cannot be formulated as solution and therefore innovator has prepared soft gelatin capsule with oil base i.e. suspended in a lipophilic fill mix. Innovator’s product (Ofev) is not available in India, so in this research, we first prepared innovator’s product (Derived on the basis of literature) and then prepared product similar to innovator’s product which is cost effective. For evaluation of product, in-vitro anal. data was compared with data available for innovator’s product literature. The product similar to innovator was successfully developed and compared with available literature. This study involved multiple reactions and reactants, such as (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6HPLC of Formula: 656247-18-6).

(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.HPLC of Formula: 656247-18-6

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Development and validation of RP-HPLC method for the estimation of nintedanib esylate in bulk and its formulation was written by Patil, Rohan S.;Mahajan, Moreshwar P.. And the article was included in Research & Reviews: A Journal of Pharmaceutical Science in 2018.Synthetic Route of C33H39N5O7S The following contents are mentioned in the article:

A review. A simple, precise, reliable, rapid and reproducible reversed-phase high performance liquid chromatog. method (RP-HPLC) method has was developed and validated for the estimation of Nintedanib Esylate. Chromatog. was carried out with anal. technol. HPLC system consisted of UV-3000-M detector on C18 (4.6×250 mm, 5μ) column with a mobile phase composed of methanol:water (80:20 volume/volume) at a flow rate of 1 mL/min. The pH of the mobile phase was adjusted by 0.05% ortho phosphoric acid (pH-3). Detection was carried out using a UV detector at 287 nm. Parameters such as linearity, precision, accuracy, ruggedness, robustness, LOD and LOQ were studied as per the ICH Q2 (R1) guidelines. The retention time was found to be 4.67 min. The linearity range for Nintedanib esylate was 10-60μg/mL. The correlation coefficient was found to be 0.999. Developed method was found to be accurate, precise, selective and rapid for estimation of Nintedanib esylate in pharmaceutical dosage form. The proposed method can be useful in quality control of bulk manufacturing and pharmaceutical dosage form. This study involved multiple reactions and reactants, such as (Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6Synthetic Route of C33H39N5O7S).

(Z)-Methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate ethanesulfonate (cas: 656247-18-6) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Synthetic Route of C33H39N5O7S

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Facile synthesis of surface functionalized Pd²⁺@P-CDP/COFs for highly sensitive detection of norfloxacin drug based on the host-guest interaction was written by Zhang, Cong;Fan, Limin;Ren, Jujie;Cui, Min;Li, Na;Zhao, Haiyan;Qu, Yihang;Ji, Xueping. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2022.Product Details of 70458-96-7 The following contents are mentioned in the article:

In this work, β-cyclodextrin porous polymers (P-CDPs) functionalized novel covalent organic frameworks (P-CDPs/COFs) were synthesized by a simple and facile method. After combined with Pd²⁺ via electrostatic interaction, the Pd²⁺@P-CDPs/COFs nanocomposites were prepared and utilized as novel electrode materials to fabricate the non-enzyme electrochem. sensors for high-sensitivity detection of Norfloxacin (NF). Due to the host-guest recognition, excellent adsorption performance and catalytic performance of Pd²⁺@P-CDPs/COFs, the prepared sensor exhibited excellent electrochem. performance for detecting NF under the optimum conditions, which showed two linear ranges of 0.08-7.0 μM and 7.0-100.0 μM with a low detection limit of 0.031 μM (S/N = 3). Addnl., the obtained sensor has also been successfully applied to measure NF with satisfactory results in the real medicinal samples of NF eye-drops. Our findings paved the way for the development of COFs-based sensing platform in drug anal. and testing for human health, food security and the quality control of drugs. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Product Details of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Product Details of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

High-throughput screening of 756 chemical contaminants in aquaculture products using liquid chromatography/quadrupole time-of-flight mass spectrometry was written by Bai, Mingkai;Tang, Ruixue;Li, Guorong;She, Wenhai;Chen, Gangjun;Shen, Hongmei;Zhu, Suqin;Zhang, Hongwei;Wu, Haohao. And the article was included in Food Chemistry: X in 2022.Related Products of 70458-96-7 The following contents are mentioned in the article:

A high-throughput screening method embracing 756 multiclass chem. contaminants in aquaculture products was developed using modified QuEChERS extraction coupled with liquid chromatog./quadrupole time-of-flight mass spectrometry. A mega-database with retention time/accurate mass data for 524 pesticides, 182 veterinary drugs, 32 persistent organic pollutants and 18 marine toxins was established for compound identification via retrospective library searching. In the four representative matrixes (muscle tissues of tilapia and grouper, and edible portions of oyster and scallop), all the database compounds showed acceptable recovery and repeatability with the screening detection limit and limit of quantification below 0.01 mg/kg for >90% of them. The matrix-matched calibration revealed acceptable quant. property of the method in terms of linear range, linearity, and matrix effect, and fish muscle samples showed stronger matrix effect than shellfish samples. Anal. of 64 real-life samples from aquaculture farms and retail markets evidenced applicability of the proposed method to high-throughput screening scenarios. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Related Products of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Related Products of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Comprehensive survey and health risk assessment of antibiotic residues in freshwater fish in southeast China was written by Hua, Yongyou;Yao, Qinghua;Lin, Jian;Li, Xi;Yang, Yan. And the article was included in Journal of Food Composition and Analysis in 2022.Category: piperazines The following contents are mentioned in the article:

To assess the health risks from antibiotic residues in freshwater fish, this study analyzed residues of 65 antibiotics in 10 freshwater fish species sampled in southeast China. Eight antibiotics were detected by UPLC-MS/MS at an overall detection rate of 53.9 %, with 3.48 % of samples exceeding MRLs and 13.0 % suggesting the misuse of human antibiotics. Quinolones, particularly enrofloxacin, were the most frequently detected residues. Azithromycin, an antibiotic intended only for human use, was detected at a rate of 14.8 % at concentrations up to 453.1 μg/kg. Antibiotic residues varied in category and concentration across freshwater fish species. Residues were detected in benthic predatory fish at higher levels than in middle or upper omnivorous or herbivorous fish. Estimated daily intakes showed that the consumption of cultured fish from this region does not pose a serious risk to human health, the hazard index being less than one. However, these findings suggest that the abuse of antibiotics in aquaculture is still a problem, and more attention should be paid to their residues in fish to enhance food safety. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Category: piperazines

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Isolation and characterisation of Pulsatilla Radix-utilising bacteria Pediococcus pentosaceus PR-1 from human faeces. was written by Liu, Yue;Sun, Xiaoxia;Zhang, Jincan;Gao, Feng;Yu, Leilei;Dong, Lina;Zhang, Gangli;Wu, Changxin. And the article was included in FEMS microbiology letters in 2022.Reference of 70458-96-7 The following contents are mentioned in the article:

Although probiotics have been isolated from different sources, few were isolated from traditional Chinese medicine. The current study firstly isolates Pulsatilla Radix-utilising Pediococcus pentosaceus PR-1 from human faeces. Subsequently, the tolerance of PR-1 to low pH, bile salts, simulated gastric juice and succus entericus, antioxidant activity, antimicrobial activity, cholesterol assimilation and antibiotics susceptibility were investigated. After 2 h of incubation at pH 2.0, over 80% of PR-1 survived. The cell viability of PR-1 at 2 h under 0.1% bile salt condition was 99.2%. The survival rate of PR-1 in gastric juice and succus entericus was 64.48% and 81.86%, respectively. Cell-free supernatant of PR-1 culture also showed antimicrobial activity against Escherichia coli, Staphylococcus aureus and Salmonella typhimurium. Besides, antioxidant activity of PR-1 CFS was significantly greater than cell pellet. PR-1 was shown to be resistant to kanamycin, streptomycin, vancomycin and norfloxacin and was able to lower the cholesterol level to 72.5±1.5%. In addition, PR-1 displayed γ-haemolysis and was non-pathogenic. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Reference of 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. The piperazine scaffold is often found in biologically active compounds in different therapeutic areas. These therapeutic areas include antifungals, antidepressants, antivirals, and serotonin receptor (5-HT) antagonists/agonists. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Reference of 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Synchronously activated strontium aluminate nanoflakes anchored functionalized carbon nanofiber nanocomposite for sensitive amperometric detection of food additive: Propyl gallate was written by Priscillal, I. Jenisha Daisy;Wang, Sea-Fue. And the article was included in Food Chemistry in 2022.Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

The contemporary dietary pattern is ruined by taste enhancers, flavoring agents, and preservatives. Pr gallate (PG) is an imperative phenolic antioxidant cast-off to inhibit the oxidative mutilation in foodstuffs thereby preventing rancidity. Determination and annihilation of PG are extensively concerned because of its probable lethal effects on human well-being. Herein, we report an electrochem. sensor using SrAl2O4/f-CNF nanocomposite as an efficient electrode modifier with peculiar synergistic quantum confinement effects supporting the formation of heterojunction to facilitate electron transportation between its counterparts. The structural, morphol., and crystalline features of SrAl2O4/f-CNF nanocomposite was thoroughly examined The proposed sensor possesses a wide linear range (0.1-1104.75μM) with a remarkably low limit of detection (0.075μM) and sensitivity (1.142μA·μM^-1·cm^-2) measured at 0.2 V (vs. Ag/AgCl). The reliability of this sensor was evidenced through real-time monitoring of PG in edible oil which is beneficial for food quality monitoring and dropping the danger of abuse of PG in foods. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. Two common salts in the form of which piperazine is usually prepared for pharmaceutical or veterinary purposes are the citrate, 3C4H10N2.2C6H8O7 (i.e. containing 3 molecules of piperazine to 2 molecules of citric acid), and the adipate, C4H10N2.C6H10O4 (containing 1 molecule each of piperazine and adipic acid).Name: 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Human daily dietary intakes of antibiotic residues: Dominant sources and health risks was written by Ben, Yujie;Hu, Min;Zhong, Fengxia;Du, Erhu;Li, Yu;Zhang, Hong;Andrews, Charles B.;Zheng, Chunmiao. And the article was included in Environmental Research in 2022.SDS of cas: 70458-96-7 The following contents are mentioned in the article:

Antibiotic use in crops is an emerging concern, however, human exposure to antibiotics residues through consumption of plant-derived food has generally been neglected. This study is a comprehensive evaluation based on full consideration of exposure sources and anal. for nearly 100 antibiotics. A total of 58 antibiotic compounds were detected in drinking water (n = 66) and 49 in food samples (n = 150) from Shenzhen, China. The probable daily intake from drinking water and food consumption based on the total concentration of all the detected antibiotic compounds was 310, 200, and 130 ng/kg-body weight/day for preschool children, adolescents, and adults, with a maximum of up to 1400, 970 and 530 ng/kg-bw/day, resp. Consumption of plant-derived food products, rather than animal-derived food, was the main source of the daily intake, and drinking water was a minor source. Risk assessment suggested a potentially unacceptable health risk from daily intake of norfloxacin, lincomycin and ciprofloxacin. Further research is warranted to alleviate food safety concerns related to antibiotic residues in plant-derived and animal-derived food products. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7SDS of cas: 70458-96-7).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.SDS of cas: 70458-96-7

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Towards the rapid detection of multiple antibiotics in eggs by Surface-enhanced Raman spectroscopy coupled with hollow fiber micro-extraction was written by Jin, Mengke;Wang, Xue;Russel, Mohammad;Shan, Jiajia. And the article was included in Microchemical Journal in 2022.Safety of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid The following contents are mentioned in the article:

Surface-enhanced Raman Spectroscopy (SERS) is an alternative tool in the field of food safety detection. Complicated food sample preparations are the key challenges to use SERS anal. for rapid food test. This study proposed a novel, facile and sensitive hollow fiber liquid-phase micro-extraction coupled with SERS (HF-LPME-SERS) technique for rapid detection of multiple antibiotic residues in eggs samples. The parameters affecting the extraction efficiency were optimized, and the optimized HF-LPME method could extract antibiotics from egg samples directly. That is eased up to sample preparation steps and promotes the SERS to rapid food testing. Moreover, here reported a simple preparation and cost-effective laser induced self-assembly SERS substrate; and applied it to SERS spectra measurement of the extract The min. detection concentration was 10 ng/g achieved for multiple antibiotics, which demonstrated the superior SERS performance. The proposed HF-LPME-SERS method provides easy sample operation, low reagent cost and high sensitivity, which would be a green and rapid anal. approach to detect the trace amount of hazardous substances in food. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Safety of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.Safety of 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Effective norfloxacin elimination via photo-Fenton process over the MIL-101(Fe)-NH₂ immobilized on α-Al₂O₃ shee was written by Zhao, Qian;Wang, Chong-Chen;Wang, Peng. And the article was included in Chinese Chemical Letters in 2022.Formula: C16H18FN3O3 The following contents are mentioned in the article:

MIL-101(Fe)-NH₂@Al₂O₃ (MA) catalysts were successfully synthesized by reactive seeding (RS) method on α-Al₂O₃ substrate, which demonstrated excellent photo-Fenton degradation performance toward fluoroquinolone antibiotics (i.e., norfloxacin, ciprofloxacin, and enrofloxacin). The structure and morphol. of the obtained MA were characterized by transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HRTEM), at. force microscope (AFM). The as-prepared MA could accomplish > 90% of norfloxacin degradation efficiency for 10 cycles’ photo-Fenton processes, owing to its excellent chem. and water stability. In addition, the effects of operational factors including H₂O₂ concentration, foreign ions, and pH on the photo-Fenton degradation of norfloxacin over MA were clarified. The ESR spectra further document that ·O₂^–, ¹O₂ and ·OH radicals are prominent in the decomposition process of antibiotic mols. Finally, the plausible photo-Fenton norfloxacin degradation mechanisms were proposed and verified. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Formula: C16H18FN3O3).

1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. A form in which piperazine is commonly available industrially is as the hexahydrate, C4H10N2. 6H2O, which melts at 44 °C and boils at 125–130 °C. Piperazines are very broad chemical group, covering a wide range of drugs from antidepressants to antihistamines. The connecting property of all these chemicals is the presence of a piperazine functional group.Formula: C16H18FN3O3

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics