Mazzei, Mauro published the artcileActivity of Mannich bases of 7-hydroxycoumarin against Flaviviridae, Quality Control of 87179-40-6, the publication is Bioorganic & Medicinal Chemistry (2008), 16(5), 2591-2605, database is CAplus and MEDLINE.
Some Mannich bases of 7-hydroxycoumarin (2) and their simple derivatives (3 and 4) were prepared and tested against viruses containing single-stranded, pos.-sense RNA genomes (ssRNA+). This study was directed toward Flaviviridae and, in particular, HCV surrogate viruses (BVDV, YFV). The 7-hydroxy derivatives 2 were generally devoid of activity, but when position 7 was propylated, the resulting 7-propyloxy derivatives 3 were in some cases endowed with an interesting activity against BVDV. The formation of 7-benzoyl derivatives 4 gave compounds generally lacking in activity against Flaviviridae, whereas the appearance of activity against RSV has been observed Also some unsym. methylene derivatives 5-7 (namely coumarins bridged to chromones or indoles) were found moderately active in antiviral tests. Derivatives 3 were submitted to a mol. modeling study using DNA polymerase of HCV as a target. The good correlation between calculated mol. modeling IC50 and exptl. EC50 indicates that DNA polymerase is potentially involved in the inhibition of surrogate HCV viruses.
Bioorganic & Medicinal Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Quality Control of 87179-40-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics