Guo, Jia-Lin published the artcileSynthesis and biological evaluation of 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives as novel PI3Kδ inhibitors, Recommanded Product: 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, the publication is Chinese Chemical Letters (2015), 26(10), 1283-1288, database is CAplus.
An efficient synthesis of novel 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine scaffold has been designed and developed. A series of 5-phenylurea derivatives I [R1 = H, CH2CH2NMe2, iso-Pr, etc.; R2 = Bn, H, or Et] were synthesized using this method. Their cytotoxic activities against breast cancer cell line BT-474 were evaluated by CCK-8 assay. Most of them showed potent anti-proliferative activities, of which compound 20 (I, R1 = CH2CH2F and R2 = Bn) and 21 (I, R1 = Me and R2 = Bn) exhibited IC50s of 1.565 and 1.311 μM, resp. Furthermore, compound 20 and 21 also showed potent inhibitory activities against PI3Kδ with IC50s of 0.286 and 0.452 μM, resp. These results indicate that these 3-(piperidin-4-yl)isoxazolo[4,5-d]pyrimidine derivatives are novel antitumor agents through the inhibition of PI3Kδ.
Chinese Chemical Letters published new progress about 55403-35-5. 55403-35-5 belongs to piperazines, auxiliary class Pyridine,Piperazine,Amine, name is 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, and the molecular formula is C10H16N4, Recommanded Product: 6-(4-Methylpiperazin-1-yl)pyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics