Facile synthesis of surface functionalized Pd2+@P-CDP/COFs for highly sensitive detection of norfloxacin drug based on the host-guest interaction was written by Zhang, Cong;Fan, Limin;Ren, Jujie;Cui, Min;Li, Na;Zhao, Haiyan;Qu, Yihang;Ji, Xueping. And the article was included in Journal of Pharmaceutical and Biomedical Analysis in 2022.Product Details of 70458-96-7 The following contents are mentioned in the article:
In this work, β-cyclodextrin porous polymers (P-CDPs) functionalized novel covalent organic frameworks (P-CDPs/COFs) were synthesized by a simple and facile method. After combined with Pd2+ via electrostatic interaction, the Pd2+@P-CDPs/COFs nanocomposites were prepared and utilized as novel electrode materials to fabricate the non-enzyme electrochem. sensors for high-sensitivity detection of Norfloxacin (NF). Due to the host-guest recognition, excellent adsorption performance and catalytic performance of Pd2+@P-CDPs/COFs, the prepared sensor exhibited excellent electrochem. performance for detecting NF under the optimum conditions, which showed two linear ranges of 0.08-7.0 μM and 7.0-100.0 μM with a low detection limit of 0.031 μM (S/N = 3). Addnl., the obtained sensor has also been successfully applied to measure NF with satisfactory results in the real medicinal samples of NF eye-drops. Our findings paved the way for the development of COFs-based sensing platform in drug anal. and testing for human health, food security and the quality control of drugs. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Product Details of 70458-96-7).
1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Although many piperazine derivatives occur naturally, piperazine itself can be synthesized by reacting alcoholic ammonia with 1,2-dichloroethane, by the action of sodium and ethylene glycol on ethylene diamine hydrochloride, or by reduction of pyrazine with sodium in ethanol.Product Details of 70458-96-7
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics