New intermediates for the selective synthesis of 1-methyl-3-phenylpiperazine and some phenylpiperazine derivatives was written by Rao, Divvela V. N. Srinivasa;Dandala, Ramesh;Handa, Vijay Kumar;Sivakumaran, Meenakshisunderam;Naidu, Andra. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2006.Electric Literature of C15H20N2O3 The following contents are mentioned in the article:
New intermediates 4-protected-1-alkyl-2-oxo-3-phenylpiperazines and 1-alkyl-2-oxo-3-phenylpiperazines for the selective synthesis of 1-alkyl-3-phenylpiperazines, e.g., I, are described. First method involves the reduction of the 4-protected-1-alkyl-2-oxo-3-phenylpiperazines followed by deprotection giving the 1-alkyl-3-phenylpiperazines. Second method involves the deprotection of 4-protected-1-alkyl-2-oxo-3-phenylpiperazines followed by reduction giving the 1-alkyl-3-phenylpiperazines. This study involved multiple reactions and reactants, such as tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3Electric Literature of C15H20N2O3).
tert-Butyl 3-oxo-2-phenylpiperazine-1-carboxylate (cas: 911705-40-3) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Electric Literature of C15H20N2O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics