Liquid-liquid microextraction with hydrophobic deep eutectic solvent followed by magnetic phase separation for preconcentration of antibiotics was written by Pochivalov, Aleksei;Cherkashina, Ksenia;Sudarkin, Andrey;Osmolowsky, Mikhail;Osmolovskaya, Olga;Krekhova, Firuza;Nugbienyo, Lawrence;Bulatov, Andrey. And the article was included in Talanta in 2023.Category: piperazines The following contents are mentioned in the article:
This study describes a miniaturized approach for liquid-liquid microextraction based on mass transfer into low volume of deep eutectic solvent and magnetic phase separation, using specially produced magnetic chromium dioxide nanoparticles with a hydrophobic surface layer of fatty acids. The nanoparticles modified with fatty acid helped to recover low volumes of viscous hydrophobic deep eutectic solvent-based extract reproducibly and easily (up to 10 μL) in a microextraction procedure with the application of magnetic forces. It was demonstrated that the collector properties depend on nanoparticles′ surface and magnetic characteristics. The developed approach was implemented for the separation and preconcentration of trace fluoroquinolone antibiotics from environmental waters prior to their determination by high-performance liquid chromatog. with fluorometric detection as a model anal. task. The limits of detection, calculated from a blank test based on 3σ, were 0.01 μg L-1 for ofloxacin, 0.02 μg L-1 for lomefloxacin and fleroxacin, and 0.04 μg L-1 for norfloxacin. The procedure provides significant solvent reduction and high enrichment factors. The approach is green, which is proved by the anal. eco-scale assessment tool with the total score equal to 85 out of 100. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7Category: piperazines).
1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Simple N-substituted piperazines have been found in many drug molecules. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics