Acquisition of blaIMP-13 on a novel IncP-7 plasmid in XDR VIM-2-positive Pseudomonas aeruginosa belonging to the global high-risk clone ST235 in an agricultural ecosystem was written by Lopes, Ralf;Furlan, Joao Pedro Rueda;Stehling, Eliana Guedes. And the article was included in Journal of Global Antimicrobial Resistance in 2022.COA of Formula: C16H18FN3O3 The following contents are mentioned in the article:
Carbapenem-resistant Pseudomonas aeruginosa strains are designated by the World Health Organization (WHO) as critical priority pathogens, which seriously limit the current treatment options. A number of genes encoding metallo-β-lactamases (MBLs) have become associated with ST235, which has promoted their dissemination. VIM-2 and IMP-13 MBLs exhibit a broad-spectrum activity and their intercontinental spread has been reported in hospital outbreaks. During a surveillance study conducted to monitor the occurrence of priority pathogens in crops, one carbapenem-resistant P. aeruginosa strain, named S810, was isolated from an agricultural soil sample with a history of cattle manure use. Antimicrobial susceptibility testing was performed by disk diffusion, broth microdilution, and/or agar dilution methods according to Clin. and Laboratory Standards Institute (CLSI) guidelines (M100, 31sted.). Strain S810 was classified as extensively drug-resistant (XDR) because it presented resistance to piperacillin-tazobactam (128/4mg/L), ceftazidime (64 mg/L), cefepime (64 mg/L), aztreonam (32mg/L), imipenem (128 mg/L), meropenem (128 mg/L), gentamicin (256 mg/L), tobramycin, amikacin, ciprofloxacin (128 mg/L), norfloxacin, lomefloxacin, ofloxacin, and levofloxacin, but it was susceptible to colistin (0.5 mg/L). This is the first report of the blaIMP-13 gene in Brazil, co-production of VIM-2 and IMP-13 in a single bacteria species, and a fully sequenced blaIMP-13-carrying plasmid. The detection of blaIMP-13 and blaVIM-2 in an XDR P. aeruginosa strain of the ST235 epidemic lineage in agricultural soil represents a threat to food and environmental safety. Therefore, continued monitoring of critical priority bacteria in crops remains necessary to effectively limit the spread of high-risk clones. This study involved multiple reactions and reactants, such as 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7COA of Formula: C16H18FN3O3).
1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid (cas: 70458-96-7) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.COA of Formula: C16H18FN3O3
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics