Zhang, Dengyou published the artcileNovel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors, Safety of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(8), 2408-2413, database is CAplus and MEDLINE.
A series of novel 5-(benzyloxy)pyridin-2(1H)-ones were designed, synthesized and biol. evaluated for c-Met inhibition. Various amides and benzimidazoles at the C-3 position were investigated. A potent compound I with a c-Met IC50 of 12 nM was identified. This compound exhibited potent inhibition of EBC-1 cell associated with c-Met constitutive activation and showed high selectivity for c-Met than other tested 11 kinases. The binding model I with c-Met was disclosed by docking anal.
Bioorganic & Medicinal Chemistry Letters published new progress about 55403-35-5. 55403-35-5 belongs to piperazines, auxiliary class Pyridine,Piperazine,Amine, name is 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, and the molecular formula is C13H19Br2ClN2O, Safety of 6-(4-Methylpiperazin-1-yl)pyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics