Srivastava, Sanjay K. published the artcileSynthesis of 13-amino costunolide derivatives as anticancer agents, SDS of cas: 87179-40-6, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(16), 4195-4199, database is CAplus and MEDLINE.
A number of amino derivatives of costunolide have been synthesized and evaluated for their in vitro cytotoxicity against eight tumor and a non-tumor cell lines. For example, costunolide amino derivative I (R = 3-methylpiperidin-1-yl) showed around 2-fold better cytotoxicity against SW-620 (colon) cell line with improved safety index than costunolide (II). While I (R = 4-hydroxypiperidin-1-yl, 3-hydroxypyrrolidin-1-yl, dimethylamino) have shown around 2- to 3-fold better cytotoxicity against MIAPaCa2 (pancreas), K-562 (leukemia) and PA-1 (ovary) cell lines as well as better safety index in comparison to II. I (R = dimethylamino) also exhibited cytotoxicity against HBL100 (breast) cell line with 2-fold better safety index. Structure-activity relationship has been described.
Bioorganic & Medicinal Chemistry Letters published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C7H8BClO2, SDS of cas: 87179-40-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics