Siu, Tony published the artcileDiscovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors, Quality Control of 55403-35-5, the publication is Bioorganic & Medicinal Chemistry Letters (2008), 18(14), 4186-4190, database is CAplus and MEDLINE.
This paper describes the improvement of cell potency in a class of allosteric Akt 1 and 2 inhibitors. Key discoveries include identifying the solvent exposed region of the mol. and appending basic amines to enhance the physiochem. properties of the mols. Findings from the structure-activity relationships are discussed.
Bioorganic & Medicinal Chemistry Letters published new progress about 55403-35-5. 55403-35-5 belongs to piperazines, auxiliary class Pyridine,Piperazine,Amine, name is 6-(4-Methylpiperazin-1-yl)pyridin-3-amine, and the molecular formula is C9H8BNO2, Quality Control of 55403-35-5.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics