Meuldermans, W. published the artcileExcretion and metabolism of flunarizine in rats and dogs, Synthetic Route of 87179-40-6, the publication is Arzneimittel-Forschung (1983), 33(8), 1142-51, database is CAplus and MEDLINE.
The excretion and metabolism of flunarizine (I) [52468-60-7] were studied after single oral doses in rats and dogs using tritium-labeled as well as 14C-labeled drug. I was well absorbed in both species. The mass balance for the unchanged drug and its major metabolites in urine, bile and feces allowed an explanation of the differences observed for the excretion pattern of the radioactivity in I [13C] and I [3H] dosed rats and in male and female rats. The main metabolic pathway in male rats was the oxidative N-dealkylation resulting in bis(4-fluorophenyl)methanol [365-24-2] and a number of complementary metabolites of the cinnamylpiperazine moiety, of which hippuric acid [495-69-2] was the main one. In female rats and male dogs, however, 4-hydroxyflunarizine [87166-81-2] was the main metabolite, resulting from the aromatic hydroxylation of the Ph ring of the cinnamyl moiety. Enterohepatic circulation of bis(4-fluorophenyl)methanol and hydroxyflunarizine was proved by donor-acceptor coupling in rats; in bile and urine, these two metabolites were present mainly as glucuronides. The glucuronide of hydroxyflunarizine [87179-38-2] was also the main plasma metabolite in dogs.
Arzneimittel-Forschung published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, Synthetic Route of 87179-40-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics