Irie, Osamu published the artcileDiscovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain, Synthetic Route of 67914-60-7, the publication is Journal of Medicinal Chemistry (2008), 51(18), 5502-5505, database is CAplus and MEDLINE.
Cathepsin S inhibitors are well-known to be an attractive target as immunol. therapeutic agents. Recently, our gene expression anal. identified that cathepsin S inhibitors could also be effective for neuropathic pain. Herein, we describe the efficacy of selective cathepsin S inhibitors as antihyperalgesics in a model of neuropathic pain in rats after oral administration.
Journal of Medicinal Chemistry published new progress about 67914-60-7. 67914-60-7 belongs to piperazines, auxiliary class Piperazine,Benzene,Phenol,Amide, name is 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone, and the molecular formula is C12H16N2O2, Synthetic Route of 67914-60-7.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics