Civiello, Rita L. published the artcileSynthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines, Synthetic Route of 180698-19-5, the publication is Bioorganic & Medicinal Chemistry Letters (2016), 26(4), 1229-1232, database is CAplus and MEDLINE.
Calcitonin gene-related peptide (CGRP) is a potent neuropeptide implicated in the pathophysiol. of migraine. In seeking CGRP antagonists with improved oral bioavailability, metabolic stability, and pharmacokinetic properties, lower mol. weight, structurally simpler piperidine and piperazine analogs of BMS-<694153≥ were prepared Several have nM binding affinity in vitro. The synthesis and SAR of these substituted piperidine and piperazine CGRP antagonists are discussed.
Bioorganic & Medicinal Chemistry Letters published new progress about 180698-19-5. 180698-19-5 belongs to piperazines, auxiliary class Piperazine,Benzene, name is 1-Biphenyl-4-yl-piperazine, and the molecular formula is C16H18N2, Synthetic Route of 180698-19-5.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics