Capuano, Ben published the artcileSynthesis and Preliminary Pharmacological Evaluation of 4′-Arylalkyl Analogs of Clozapine. III. Replacement of the Tricyclic Nucleus with a Bicyclic Template, SDS of cas: 87179-40-6, the publication is Australian Journal of Chemistry (2007), 60(12), 928-933, database is CAplus.
As a continuing part of our research program in search of novel compounds for the treatment of schizophrenia, we report the synthesis and preliminary receptor binding affinity for a series of bicyclic analogs of clozapine [I; Y = CH2, Z = H, 3,4-OCH2O, 3-OMe, 4-OMe; Y = CH2CH2, (CH2)3, (E)-CH:CHCH2, Z = H] derived from a selection of promising tricyclic candidates published previously. These bicyclic compounds investigate some substituent effects and the length and nature of the linker between an ionizable nitrogen atom at physiol. pH and the introduced aryl moiety. The chem., structural characterization, and in vitro evaluation are described. Preliminary findings on the effects on activity of the nature and length of the linker, degree of unsaturation, and selected substituents coupled to the bicyclic nucleus are discussed in relation to affinity for dopamine D4 and serotonin 5-HT2A receptors.
Australian Journal of Chemistry published new progress about 87179-40-6. 87179-40-6 belongs to piperazines, auxiliary class Benzenes, name is (E)-1-Cinnamylpiperazine, and the molecular formula is C13H18N2, SDS of cas: 87179-40-6.
Referemce:
https://en.wikipedia.org/wiki/Piperazine,
Piperazines – an overview | ScienceDirect Topics