Segawa, Jun published the artcileStudies on pyridonecarboxylic acids. 1. Synthesis and antibacterial evaluation of 7-substituted-6-halo-4-oxo-4H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids, Synthetic Route of 113028-17-4, the main research area is thiazetoquinolinecarboxylic acid derivative preparation bactericide.
A series of [1,3]thiazeto[3,2-a]quinoline-3-carboxylic acids (I) and their esters were prepared and evaluated for antibacterial activity. The derivatives with an H or Me group at C-1, F at C-6, and a piperazinyl or 4-methyl-1-piperazinyl group at C-7 showed superior in vitro antibacterial activity, and the derivatives with 4-methyl-1-piperazinyl group at C-7 had potent in vivo activity. I (R = piperazino) (NM394) showed excellent in vitro antibacterial activity and low toxicity but poor absorption from the gastrointestinal tract. I [R = (5-methyl-2-oxo-1,3-dioxol-4-yl)methylpiperazino) (NM441) had a favorable pharmacokinetic profile and oral activity superior to that of ciprofloxacin in exptl. animals.
Journal of Medicinal Chemistry published new progress about thiazetoquinolinecarboxylic acid derivative preparation bactericide. 113028-17-4 belongs to class piperazines, name is Ethyl 6-fluoro-1-methyl-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-[1,3]thiazeto[3,2-a]quinoline-3-carboxylate, and the molecular formula is C18H20FN3O3S, Synthetic Route of 113028-17-4.
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics