Chu, Daniel T. W.’s team published research in Canadian Journal of Chemistry in 1992-05-31 | CAS: 105784-61-0

Canadian Journal of Chemistry published new progress about temafloxacin; methylpiperazinylfluorodifluorophenyldihydrooxoquinolinecarboxylic acid; quinolinecarboxylic acid methylpiperazinylfluorodifluorophenyldihydrooxo; piperazinylphenylquinolinecarboxylic acid. 105784-61-0 belongs to class piperazines, name is Temafloxacin hydrochloride, and the molecular formula is C21H19ClF3N3O3, Related Products of piperazines.

Chu, Daniel T. W. published the artcileAn alternative synthesis of temafloxacin, a potent antibacterial agent, Related Products of piperazines, the main research area is temafloxacin; methylpiperazinylfluorodifluorophenyldihydrooxoquinolinecarboxylic acid; quinolinecarboxylic acid methylpiperazinylfluorodifluorophenyldihydrooxo; piperazinylphenylquinolinecarboxylic acid.

An alternative synthesis of (methylpiperazinyl)fluoro(difluorophenyl)dihydrooxoquinolinecarboxylic acid (temafloxacin) hydrochloride I, a potent antibacterial agent, was developed. The method was characterized by regiospecific displacement of the 4-fluoro of the 2,4,5-trifluoroacetophenone by 2-methylpiperazine to produce the key intermediate, 2,5-difluoro-4-(3-methylpiperazin-1-yl)acetophenone (II), which was subsequently converted to I via an intramol. nucleophilic displacement cyclization reaction.

Canadian Journal of Chemistry published new progress about temafloxacin; methylpiperazinylfluorodifluorophenyldihydrooxoquinolinecarboxylic acid; quinolinecarboxylic acid methylpiperazinylfluorodifluorophenyldihydrooxo; piperazinylphenylquinolinecarboxylic acid. 105784-61-0 belongs to class piperazines, name is Temafloxacin hydrochloride, and the molecular formula is C21H19ClF3N3O3, Related Products of piperazines.

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics