On January 31, 1992, Lin, Guoquan; Lu, Zhufen; Xu, Jiemei; Ouyang, Weiying published an article.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the article was Facile salt formation of ciprofloxacin hydrochloride monohydrate. And the article contained the following:
Crude cirpofloxacin hydrochloride monohydrate was dissolved in water containing 0.09 mol concentrated HCl, decolorized with active carbon, crystallized on cooling, and recrystallized from 85% EtOH after filtration and washing with absolute EtOH; the yield was 80.7%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to ciprofloxacin hydrochloride monohydrate recrystallization, Pharmaceuticals: Pharmaceutics and other aspects.Application In Synthesis of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics