On March 28, 2002, Singh, Onkar N.; Bhagat, Haresh G.; Kabra, Bhagwati P. published a patent.Category: piperazines The title of the patent was Topical composition comprising ciprofloxacin and hydrocortisone. And the patent contained the following:
This invention is directed toward a topical composition comprising ciprofloxacin and hydrocortisone, where the composition contains a specific grade of poly(vinyl alc.) as a viscosity augmenter. The specified grade of polyvinyl alc. is 85-90% hydrolyzed poly(vinyl alc.). Thus, a composition contained ciprofloxacin-HCl monohydrate 0.35, micronized hydrocortisone 1.9, benzyl alc. 0.9, NaCl 0.9, sodium acetate trihydrate 0.68, acetic acid 0.255, Phospholipon 90H 0.15, Polysorbate-20 0.10, NaOH and/or HCl to pH 4.7, and water to 100%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Category: piperazines
The Article related to topical ciprofloxacin hydrocortisone, Pharmaceuticals: Formulation and Compounding and other aspects.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics