On December 31, 2008, Pastini, Ana C.; Faour, Joaquina; Vergez, Juan A.; Ricci, Marcelo A.; Fischbein, Gustavo A. published a patent.Recommanded Product: 86393-32-0 The title of the patent was A rupturing controlled release device comprising a subcoat. And the patent contained the following:
The present invention provides a simple and improved rupturing controlled release device that is capable of providing a controlled release of active agent contained in the core first through a preformed passageway and then through an in situ formed second passageway into an environment of use in a standardized release profile manner. The rupturing controlled release device comprises a core comprising at least one drug and at least one osmopolymer, a semipermeable membrane enclosing the core and having at least one preformed passageway there through, wherein the semipermeable membrane ruptures during use to form a second passageway in the semipermeable membrane at a location spaced away from the preformed passageway, and a release-controlling subcoat between the core and the semipermeable membrane. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Recommanded Product: 86393-32-0
The Article related to controlled release delivery rupturing, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics