On April 30, 1987, Lammens, Robert Frank; Mahler, Hans Friedrich; Serno, Peter published a patent.Electric Literature of 86393-32-0 The title of the patent was Infusion solution of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinoline-3-carboxylic acid (ciprofloxacin), especially for antibacterial use. And the patent contained the following:
Aqueous infusion solutions for especially antibacterial use contain ciprofloxacin 0.015-0.5 g/100 mL of a physiol. acceptable acid as stabilizer, with optional adjuvants. An infusion solution contained ciprofloxacin 90, lactic acid (20% g/g) 144.3, HCl 1.5, NaCl 5.4g, and water to 600 mL; its pH was ∼4.3 and osmolarity ∼0.29 osm/kg. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0
The Article related to antibacterial infusion solution ciprofloxacin acid, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics