On February 22, 2001, Fekete, Pal; Fellner, Gyorgy, Mrs.; Gora, Laszlo, Mrs.; Jambor, Istvan, Mrs.; Feikus, Szilvia; Palfi, Zoltan, Mrs.; Zsigmond, Zsolt published a patent.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate The title of the patent was Ciprofloxacin-containing pharmaceutical composition and process for the preparation thereof. And the patent contained the following:
The invention relates to an immediate-release pharmaceutical composition containing ciprofloxacin, a binder, disintegrating agent and optionally further pharmaceutical auxiliary agents. The composition comprises 60-80 % of ciprofloxacin (in the form of ciprofloxacin hydrochloride monohydrate), 2-10 % of maltodextrin, 5-15 % of a disintegrating agent of carboxymethyl starch type, 3-6 % of silica, 1-3 % of a lubricant and optional 2-6 % of a film-coating layer for film-coated tablets. A tablet contained ciprofloxacin hydrochloride monohydrate 582, Na CM starch 82, maltodextrin 40, silica 40, Mg stearate 6, and Opadry Y-1-7000 16 mg. The tablet was dissolved in the amounts of 94.3, 95.4, and 98.5 % in 5, 15, and 30 min, resp. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
The Article related to immediate release tablet ciprofloxacin, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics