On February 20, 1997, Canovas Soler, Pedro; Delgadillo Duarte, Joaquin; Moreno Rueda, Juan published a patent.Category: piperazines The title of the patent was Aqueous compositions containing ciprofloxacin. And the patent contained the following:
Aqueous compositions for treatment of otitis media with perforation of the tympanic membrane contain the broad-spectrum antibiotic ciprofloxacin.HCl.H2O 0.12-0.6 (equivalent to 0.1-0.5% free base), buffer (pH 4-5) 0.5-3.0, nonionic surface-active agent 0.05-0.3, thickening agent 0.5-2.0 g, and H2O to 100 mL. This solution is packaged in sterile single dosage units without preservatives. Thus, an aqueous solution was prepared containing ciprofloxacin.HCl.H2O 0.40, AcOH 0.45, NaOAc.3H2O 1.20, polysorbate 80 0.19, methylcellulose 1.15, and glycerin 1.62 weight%. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Category: piperazines
The Article related to ciprofloxacin solution otitis media, Pharmaceuticals: Formulation and Compounding and other aspects.Category: piperazines
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics