On July 23, 1987, Streuff, Bernd; Luchtenberg, Helmut published a patent.Electric Literature of 86393-32-0 The title of the patent was Pharmaceutical ciprofloxacin preparations. And the patent contained the following:
Pharmaceutical oral compositions contain ciprofloxacin 30.0-95.0, cellulose-based dry binder 4.5-25.0, disintegration enhancers based on starch 0-30.0 and based on cellulose derivatives and(or) polyvinyl pyrrolidone 0.5-10.0, a flowability improver 0-2.0, and a lubricant 0-3.0 weight % for optimal biol. availability and drug stability. Tablets contained ciprofloxacin.H2O 583, Avicel 55, corn starch 72, Polyplasdone XL 30, Aerosil (unpressurized) 5, and Mg stearate 5 mg, coated with Polywax 400 200, HPM-cellulose 6.2, and TiO2 2.0 mg. The experimental process involved the reaction of 1-Cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid hydrochloride hydrate(cas: 86393-32-0).Electric Literature of 86393-32-0
The Article related to ciprofloxacin oral pharmaceutical antibacterial, enterobacteria ciprofloxacin oral pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.Electric Literature of 86393-32-0
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics